2011 Fiscal Year Final Research Report
Functions of endoplasmic reticulum as a stress sensor to toxic metals exposure
| Project/Area Number |
21510073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 小胞体ストレス / 毒性金属 / 分子シャペロン / 熱ショック蛋白 / シグナル伝達 / トキシコロジー / 環境 |
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| Research Abstract |
The toxic metal, cadmium, damages renal proximal tubular cells. We, therefore, examined the protective effects of salubrinal, a suppressor of endoplasmic reticulum stress, on apoptotic cell death in HK-2 human proximal tubular cells exposed to cadmium. Treatment with salubrinal protected cadmium-exposed HK-2 cells from apoptosis by increasing the phosphorylation of translation initiation factor, eIF2α, and suppressing cell death signal transduction pathways. Endoplasmic reticulum may function as a stress sensor to toxic metals exposure.
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