2011 Fiscal Year Final Research Report
Construction of New Theoretical Modeling to Understand and Control Single Quantum Dot Intermittent Blinking
| Project/Area Number |
21510123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Hokkaido University |
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Principal Investigator |
LI Chun-biu 北海道大学, 電子科学研究所, 准教授 (90397795)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMATSUZAKI Tamiki 北海道大学, 電子科学研究所, 教授 (30270549)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 1分子計測(SMD) / 量子ドット / ナノバイオ / 物性理論 / 光物性 |
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| Research Abstract |
To elucidate the mechanisms of intermittent blinking kinetics, we developed a series of novel data-driven time series analysis and modeling techniques to extract the underlying kinetic scheme directly from single molecule (SM) quantum dot (QD) fluorescence experiments. These include the development and application of the change-point analysis that allows us to correctly extract the on and off intensity dwell-time statistics, and the development of a novel kinetic scheme (KS) construction methodology which unveils the most unbiased KS capturing the full statistical information from time series. The developed methods have demonstrated their high reliability and applicability not only in SM QD experiments, but also in a wide range of other SM measurements, such as in the SM enzymatic turnover experiments and the SM F1_ATPase rotation assessments.
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