2011 Fiscal Year Final Research Report
A research for the new animal models of ADHD by means of behavioral and physiological measurement of impulsiveness and attention.
| Project/Area Number |
21530766
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Fukuoka Prefectural University |
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Principal Investigator |
MUGISHIMA Go 福岡県立大学, 人間社会学部, 准教授 (40308143)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生理 |
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| Research Abstract |
ADHD(attention deficit hyperactivity disorder) is a developmental disorder to assume cardinal symptoms including inattention, impulsiveness and hyperactivity, which is assumed some neural dysfunctions such as higher concentration of dopamine transporter. Although medication and operant therapy are effective on this disorder, it is not clear that the functional relation between both effects. In this study, EL mouse was proposed as a new animal model of ADHD, and two kinds of impulsiveness and mismatch negativity like response were advocated as behavioral and electrophysiological indices of ADHD. Using these models and indices, I discovered some appropriate combinations of medical dosage and signal clearness on operant therapy, which may suggest the significant aspects of functional relation between these therapies. Furthermore, a cognitive dysfunction was indicated on pre-attention which is the phase before generation of attention in cerebral cortex on animal model.
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[Presentation] Effects of atomoxetine and fluoxetine on the epileptic EL mouse、a possible animal model for ADHD2011
Author(s)
Nakamoto, Y., Mugishima, G., Kimura、H., Masuda, K., Oyama, A., Kubo, H., Nukada, H., Yoshii, M.
Organizer
Society for Neuroscience
Place of Presentation
Washington D. C.(米国)
Year and Date
2011-11-16
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