2011 Fiscal Year Final Research Report
Psychological and physiological studies on circadian rhythm in the memory system
| Project/Area Number |
21530771
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Sophia University |
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Principal Investigator |
OKADA Takashi 上智大学, 総合人間科学部, 教授 (00242082)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 海馬 / 長期増強 / メラトニン / 一酸化窒素 |
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| Research Abstract |
Hippocampal long-term potentiation(LTP), which is thought of as a candidate for the physiological basis of memory, is reportedly reduced in the presence of melatonin, whose pattern of secretion shows a circadian rhythm. In this study, I electrophysiologically examined the mechanisms of inhibition of hippocampal LTP by melatonin. The inhibitory effects of an inhibitor of NO synthase and melatonin were occluded by each other, and an NO donor disrupted the inhibition of LTP, which leads to the idea that the target of melatonin for LTP inhibition is the NO pathway.
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[Journal Article] The facilitative effects of bilobalide, a unique constituent of Ginkgo biloba, on synaptic transmission and plasticity in hippocampal subfields2011
Author(s)
Suzuki, E., Sato, M., Takezawa, R., Suzuki, E., Sato, M., Takezawa, R., Usuki, T. & Okada, T
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Journal Title
Journal of Physiological Sciences
Volume: 61
Pages: 421-427
DOI
Peer Reviewed
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[Book] 認知神経科学2012
Author(s)
道又爾・岡田隆
Total Pages
1-44, 116-153, 223-276
Publisher
放送大学教育振興会
