Neuronal circuit of eyeblink conditioning in mice

2011 Fiscal Year Final Research Report

• Project/Area Number: 21530781
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental psychology
• Research Institution: University of Tsukuba
• Principal Investigator: SAKAMOTO Toshiriou 筑波大学, 教育イニシアティブ機構, 准教授 (40321765)
• Project Period (FY): 2009 – 2011
• Keywords: 瞬目反射条件づけ / 小脳 / 扁桃体 / マウス

Research Abstract

Amygdala is critical for eyeblink conditioning in mice when the salient conditioned stimulus (CS) was used. Furthermore, we conducted the tone frequency discrimination task using deep cerebellar nuclei (DCN) lesioned mice. DCN lesioned mice could not acquire the discrimination task, and the results indicate that cerebellum is critically involved in the complicated cognitive task in eyeblink conditioning.

Research Products

• [Journal Article] The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease (2010)
  • Author(s): H. J. Lee, J. K. Lee, H.Lee, J. Shin, , J. E. Carter, T. Sakamoto, H.K. Jin, J.Bae
  • Journal Title: Neuroscience Letters Volume: 481 Pages: 30-35
• [Journal Article] Amygdala, deep cerebellar nuclei and red nucleus contribute to delay eyeblink conditioning in C57BL/6mice (2010)
  • Author(s): T. Sakamoto & S. Endo
  • Journal Title: European Journal of Neuroscience Volume: 32 Pages: 1537-1551
• [Journal Article] Dual involvement of G-substrate in motor learning revealed by gene deletion (2009)
  • Author(s): S. Endo, F. Shutoh, T.L. Dinh, T. Okamoto, T. Ikeda, M. Suzuki, S. Kawahara, D.Yanagihara, Y. Sato, K. Yamada, T. Sakamoto, Y.Kirino, N.A. Hartell, K. Yamaguchi, S. Itohara, A.C. Nairn, P. Greemgard, S. Nagao, & M. Ito
  • Journal Title: Proceedings of the National Academic Sciences of the U.S.A. Volume: 106 Pages: 3525-3530
• [Journal Article] 小脳核のGABAA受容体 (2009)
  • Author(s): 坂本敏郎, 遠藤昌吾
  • Journal Title: 生体の科学 Volume: 60 Pages: 380-381
• [Presentation] Impairment of socio-emotional behavior and memory function in Draxin (Dorsal repulsive axon guidance protein) knockout mice (2011)
  • Author(s): Sakamoto, T., Shinmyo, Y., Tanaka, H., & Ogawa, S.
  • Organizer: 39^<th> Annual meeting of Society for Neuroscience
  • Place of Presentation: Washington D.C
  • Year and Date: 2011-11-14
• [Presentation] 社会的認知及び空間認知機能におけるオキシトシン受容体の役割 (2010)
  • Author(s): 佐越祥子, 坂本敏郎, 小川園子
  • Organizer: 日本動物心理学会、第70回大会
  • Place of Presentation: 帝京大学(東京都)
  • Year and Date: 20100800
• [Presentation] Impairment of socio-emotional behavior and memory function in Draxin (Dorsal repulsive axon guidance protein) knockout mice (2010)
  • Author(s): T. Sakamoto, Y. Shinmyo, H. Tanaka, & S. Ogawa
  • Organizer: 33^<th> Annual meeting of Japan Neuroscience Society
  • Place of Presentation: Kobe
  • Year and Date: 20100000
• [Presentation] 扁桃体はマウス瞬目反射条件づけに重要な役割を持つ日本動物心理学会 (2009)
  • Author(s): 坂本敏郎, 小川園子, 遠藤昌吾
  • Organizer: 第69回大会
  • Place of Presentation: 岐阜大学(岐阜県)
  • Year and Date: 20090900
• [Presentation] Lateral Amygdala plays important roles in acquisition and retention of delay eyeblink conditioning in mice (2009)
  • Author(s): T. Sakamoto, S. Ogawa & S. Endo
  • Organizer: 31^<th> Annual meeting of Japan Neuroscience Society
  • Year and Date: 20090000
• [Remarks]
  • URL: http://www.kansei.tsukuba.ac.jp/~ogawalab/?category=11