2011 Fiscal Year Final Research Report
Application of the brain functional analysis of autism spectrum disorders in order to establish an efficient medical and educational support system
| Project/Area Number |
21531035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Special needs education
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| Research Institution | Bunkyo University |
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Principal Investigator |
NARITA Naoko 文教大学, 教育学部, 教授 (40306189)
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| Project Period (FY) |
2009 – 2011
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| Keywords | セロトニン / 自閉症スペクトラム障害 / 図形課題 / 前頭前野 / 作業記憶 / スイッチングタスク |
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| Research Abstract |
We first examined prefrontal hemodynamic change according to reciprocal disposition of working memory(WM) and non-WM tasks of geometrical figures using near-infrared spectroscopy to compare high-functioning ASD subjects with controls. An evoked cerebral blood oxygenation(CBO) change was instantly observed in response to the task switch in the controls but not in ASD subjects, although the task performance rates were almost equivalent. Secondary, we measured CBO changes during facial expressions as stimuli in the same switching task. In ASD patients, no relevance between the task performance rate and the CBO change, which was shown in the controls.
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