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2011 Fiscal Year Final Research Report

Synthesis and Conformational Analysis of Amino Acids and Oligopeptides Labeled with Stable Isotopes

Research Project

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Project/Area Number 21550050
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Organic chemistry
Research InstitutionTokai University

Principal Investigator

OBA Makoto  東海大学, 開発工学部, 教授 (10246077)

Project Period (FY) 2009 – 2011
Keywords安定同位体標識 / アミノ酸 / ペプチド / 立体選択的合成 / 配座解析
Research Abstract

Facile and large-scale synthesis of stereoselectively stable isotope-labeled amino acids, which can promote the efficiency of NMR protein structure determination, was investigated. In this work, a novel synthetic method for unsaturated pyroglutaminol derivatives, key intermediates for eight kinds of labeled amino acids, has been developed and gram-scale syntheses of deuterated prolines and glutamic acids were achieved. Using the obtained proline, some dipeptides were prepared and a systematic conformational analysis was carried out. With the help of selective deuterium-labeling, it becomes feasible to monitor the proline ring puckering by means of simple 1D NMR spectroscopy.

  • Research Products

    (18 results)

All 2012 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (9 results)

  • [Journal Article] Stereoselective Synthesis of 3, 4-Dihydroxylated Prolines and Prolinols Starting from L-Tartaric Acid2012

    • Author(s)
      M. Oba, S. Koguchi, K. Nishiyama
    • Journal Title

      J. Heterocyclic Chem

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Aerobic Oxidation of Thiols to Disulfides Catalyzed by Diaryl Tellurides under Photosensitized Conditions2011

    • Author(s)
      M. Oba, K. Tanaka, K. Nishiyama, W. Ando
    • Journal Title

      J. Org. Chem

      Volume: 76 Pages: 4173-4177

    • Peer Reviewed
  • [Journal Article] Synthesis and Structure of 9, 10-Bis(2, 4, 6-triisopropylphenyl)-9, 10-dihydro-9, 10-disilaanthracene2011

    • Author(s)
      M. Oba, T. Kondo, K. Tanaka, S. Koguchi, K. Nishiyama
    • Journal Title

      J. Organomet. Chem

      Volume: 696 Pages: 982-985

    • Peer Reviewed
  • [Journal Article] 不飽和オルトピログルタミン酸エステルを用いる非タンパク性アミノ酸の立体選択的合成2010

    • Author(s)
      大場真
    • Journal Title

      東海大学紀要開発工学部

      Volume: 20 Pages: 31-40

    • Peer Reviewed
  • [Journal Article] Formation of Diaryl Telluroxides and Tellurones by Photosensitized Oxygenation of Diaryl Tellurides2010

    • Author(s)
      M. Oba, Y. Okada, M. Endo, K. Tanaka, K. Nishiyama, S. Shimada, W. Ando
    • Journal Title

      Inorg. Chem

      Volume: 49 Pages: 10680-10686

    • Peer Reviewed
  • [Journal Article] Diorganotelluride-catalyzed Oxidation of Triorganosilanes to Silanols under Atmospheric Oxygen2010

    • Author(s)
      Y. Okada, M. Oba, A. Arai, K. Tanaka, K. Nishiyama, W. Ando
    • Journal Title

      Inorg. Chem

      Volume: 49 Pages: 393-385

    • Peer Reviewed
  • [Journal Article] Facile Synthesis of Unsaturated Pyroglutaminol Derivatives2009

    • Author(s)
      M. Oba, C. Ito, T. Hayashi, K. Nishiyama
    • Journal Title

      Tetrahedron Lett

      Volume: 50 Pages: 5053-5055

    • Peer Reviewed
  • [Journal Article] Aerobic Photooxidation of Phosphite Esters Using Diorganotelluride Catalysts2009

    • Author(s)
      M. Oba, Y. Okada, K. Nishiyama, W. Ando
    • Journal Title

      Organic Letters

      Volume: 11 Pages: 1879-1881

    • Peer Reviewed
  • [Journal Article] Asymmetric Synthesis of(2S, 3R)-and(2S, 3S)- [2-^<13> C ; 3-^2H] Glutamic Acid2009

    • Author(s)
      K. Okuma, A. M. Ono, S. Tsuchiya, M. Oba, K. Nishiyama, M. Kainosho, T. Terauchi
    • Journal Title

      Tetrahedron Lett

      Volume: 50 Pages: 1482-1484

    • Peer Reviewed
  • [Presentation] 重水素標識プロリン含有ジペプチドの合成および配座解析2012

    • Author(s)
      鈴木英亮、大場真、西山幸三郎
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応大学、横浜
    • Year and Date
      20120325-28
  • [Presentation] テルリン酸無水物-テルロン付加物の合成と性質2011

    • Author(s)
      大場真、西山幸三郎、島田茂、安藤亘
    • Organizer
      第38回有機典型元素化学討論会
    • Place of Presentation
      石川県立音楽堂、金沢
    • Year and Date
      20111207-09
  • [Presentation] 酒石酸およびリボースを出発物質とするポリヒドロキシピロリジン誘導体の立体選択的合成2011

    • Author(s)
      大場真、鈴木俊裕、岡田祐子、久島広信、佐野貴紀、西山幸三郎
    • Organizer
      第41回複素環化学討論会
    • Place of Presentation
      崇城大学市民ホール、熊本
    • Year and Date
      20111020-22
  • [Presentation] ジアリールテルリドを触媒として用いるチオールの空気酸化2011

    • Author(s)
      田中和仁、大場真、西山幸三郎、安藤亘
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学、横浜
    • Year and Date
      20110326-29
  • [Presentation] Reduction of Organic Substrates in Aqueous Media Using Hypophosphorous acid-palladium System2010

    • Author(s)
      K. Kojima, M. Oba, K. Nishiyama
    • Organizer
      International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
    • Place of Presentation
      Honolulu(USA)
    • Year and Date
      20101215-20
  • [Presentation] Formation of Diaryl Telluroxides and Tellurones by Photosensitized Oxygenation of Diaryl Tellurides2010

    • Author(s)
      M. Oba, K. Tanaka, Y. Okada, K. Nishiyama, W. Ando
    • Organizer
      International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
    • Place of Presentation
      Honolulu(USA)
    • Year and Date
      20101215-20
  • [Presentation] テルロキシドを酸化剤として用いるジシランの酸化2010

    • Author(s)
      田中和仁、大場真、西山幸三郎、安藤亘
    • Organizer
      第37回有機典型元素化学討論会
    • Place of Presentation
      室蘭市民会館、室蘭
    • Year and Date
      20101125-27
  • [Presentation] 次亜リン酸-パラジウム系を用いる水系での接触還元反応2010

    • Author(s)
      小嶋華織、大場真、西山幸三郎
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学、東大阪
    • Year and Date
      20100326-29
  • [Presentation] テルリドを触媒として用いるチオールの酸化2009

    • Author(s)
      田中和仁、大場真、西山幸三郎、安藤亘
    • Organizer
      第36回有機典型元素化学討論会
    • Place of Presentation
      とりぎん文化会館、鳥取
    • Year and Date
      20091210-12

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Published: 2013-07-31  

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