2012 Fiscal Year Final Research Report
Development of chemiluminescence probe using dioxetanes responsive to a conformational change
| Project/Area Number |
21550052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Kanagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Masakatsu 神奈川大学, 理学部, 教授 (10260986)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 有機光化学 / 化学発光 / ジオキセタン / 発光プローブ |
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| Research Abstract |
An aryl-substituted dioxetane fused with N-acylpyrrolidine gave four conformational isomers due to rotation of an aryl ring around the bond joining it to a dioxetane ring and/or conformational isomerism of N-acyl group. These conformational isomers were found to become possible to be effectively isolated by design of the N-acyl group. The thus-isolated conformational isomers showed the unique chemiluminescence, the properties of which were significantly different from each other. A new dioxetane bearing a sterically congested bisnaphthol moiety was found to give chemiluminescence in the presence of a Mg alkoxide. Furthermore, the thermodynamic properties were clarified for chemiluminescent decomposition of benzothiazolylphenol-substituted dioxetanes.
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