2011 Fiscal Year Final Research Report
DNA-chip-based gene sensor based on in-situ electronical functionalization of double-helical DNA self-assemblies.
| Project/Area Number |
21550085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKANO Koji 九州大学, 工学研究院, 准教授 (10180324)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ナノバイオ / DNA / 自己組織化 / 分子認識 / バイオセンサー / 遺伝子センサー / 分子エレクトロニクス / 走査プローブ顕微鏡 |
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| Research Abstract |
DNA-based molecular device tackled for futuristic gene sensor developmentsbased on in-situ electroconductivemodification of wasDNA self-assembly. Some direct or indirect assistance necessary to the goal were successfully developed ; novel small-molecule, reative compounds that enable versatile functionalization of DNA duplexes, scanning electrochemical microscopy imaging of DNA microdots, a new potentiometric platform for gene sensing, and etc. Unfortunately, the planned strategy, dip-pen nanolithography, has not yet achieved mostly due to the mechanical instability of the DNA self-assemblies. However, are committed to taking on the challengesbyusingsome DNAnanomaterialstoprovidetheparticulawergene-sensing device.
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Research Products
(13 results)
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[Journal Article] Structure-Reactivity Relationship of Piperidine Nitroxide : Electrochemical, ESR and Computational Studies2011
Author(s)
T. Yamasaki, F. Mito, Y. Ito, S. Pandian, Y. Konoshita, K. Nakano, R. Murugesan, K. Sakai, H. Utsumi, K. Yamada
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Journal Title
J. Organic Chemistry
Volume: Vol.76, No.2
Pages: 435-440
Peer Reviewed
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