2011 Fiscal Year Final Research Report
Development of chiral organo catalysts in which different atoms cooperatively catalyze asymmetric reactions
| Project/Area Number |
21550102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Shinshu University |
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Principal Investigator |
FUJIMOTO Tetsuya 信州大学, 大学院・総合工学系研究科, 准教授 (90209099)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 不斉合成 / 反応 |
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| Research Abstract |
A novel asymmetric organocatalyst for preparation of optically active alcohol derivatives has been developed. The catalyst is a phosphinite derivative easily derived from aminoindanol whose both enantiomers are commercially available. Especially, asymmetric desymmetrization of 1, 2-diols by use of acylation reaction catalyzed by the organocatalyst gave desired chiral alcohol derivatives with high enantioselectivity and in high yield. In addition, kinetic resolution of racemic alcohols such as cyclohexylbenzyl alcohol was achieved with high level of resolution efficiency.
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[Journal Article] Enantioselective Acylationof 1, 2-and 1, 3-Diols Catalyzed by Aminophosphinite Derivatives of(1S, 2R)-1-Amino-2-indanol2012
Author(s)
Hiroyuki Aida, Kouhei Mori, YasuyukiYamaguchi, Shinya Mizuta, TomomiMoriyama, Iwao Yamamoto, TetsuyaFujimoto
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Journal Title
OrganicLetters
Volume: Vol.14, No.3
Pages: 812-815
DOI
Peer Reviewed
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