2011 Fiscal Year Final Research Report
Development of organocatalysis aiming for the preparation of important synthetic intermediates
| Project/Area Number |
21550106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | University of Shizuoka |
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Principal Investigator |
SUZUKI Yumiko 静岡県立大学, 薬学部, 講師 (20295546)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 不斉合成・反応 / 触媒設計・反応 / 環境調和型反応 / 選択的合成・反応 / 有機触媒反応 |
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| Research Abstract |
An efficient one-pot synthesis of various unsymmetrical benzils and heterocycles has been developed. NHC-catalyzed aroylation of N-phenylimidoyl chlorides with aromatic aldehydes followed by acidic hydrolysis gives benzils. A one-pot synthesis of quinoxalines and pyrazines by condensation/cyclization reaction of unsymmetrical benzils generated in situ with diamines was also achieved.
Novel C_2-symmetrical imidazolium salts were synthesized and used in kinetic resolution of secondary alcohols and in asymmetric cyanosilylation as a catalyst precursor. It was found out that substituents at 4-and 5-position of imidazole increase the reaction rates.
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