2011 Fiscal Year Final Research Report
Synthesis of Cyclophane Oligomers Having Multivalently Enhanced Guest-Binding Affinity Based on Cluster Effect
| Project/Area Number |
21550136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional materials chemistry
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Setsuko 福岡大学, 理学部, 講師 (20078562)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ホストゲスト化学 / シクロファン / クラスター効果 |
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| Research Abstract |
Water-soluble cyclophane dimer, trimer, tetramer, and pentamer were prepared by aminolysis of succinimidyl ester derivative of tetraaza[6.1.6.1] paracyclophane with lysine and the corresponding lysine peptide as a scaffold, followed by removal of the protecting groups. The present cyclophane oligomers showed enhanced guest-binding affinities toward fluorescent guests such as 6-p-toluidino-naphthalene-2-sulfonate, in comparison with those of monocyclic cyclophane, reflecting multivalency effects in macrocycles. The effects of multivalent macrocycles on the guest-binding of the present cyclophane oligomers were also confirmed by SPR measurements.
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