2011 Fiscal Year Final Research Report
Characterization of heme transport proteins from pathogenic bacteria
| Project/Area Number |
21550157
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemistry related to living body
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIGITA Taiko 山口大学, 農学部, 教授 (90159161)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | ヘム |
|---|
| Research Abstract |
Iron is involved in a wide range of essential functions in various metabolic pathways ; therefore, most bacteria have some form of iron-scavenging system in order to survive. Heme acquisition system A(HasA), secreted by various gram-negative pathogens, uses a unique histidine-iron-tyrosine(His-Fe-Tyr) or an iron-tyrosine(Fe-Tyr) coordination to scavenge heme. Our results suggest that the binding of heme in apoprotein is initiated by interactions between heme and hydrophobic residues in the heme binding pocket. Subsequent coordination of Tyr to the heme iron complete holoprotein formation.
|
-
-
-
[Journal Article] A heterodimeric cytochrome c complex with a very low redox potential from an anaerobic ammonium-oxidizing enrich2010
Author(s)
Ukita, S., Fujii, T., Hira, D., Nishiyama, T., Kawase, T., Migita, C. T., Furukawa, K.
-
Journal Title
FEMS Microbiology Letters
Volume: 313
Pages: 61-67
Peer Reviewed
-
[Journal Article] Biochemical and spectroscopic properties of cyanide-insensitive quinol oxidase from Gluconobacter oxydans2009
Author(s)
Mogi, T., Ano, Y., Nakatsuka, T., Toyama, H., Muroi, A., Miyoshi, H., Migita, C. T., Ui, H., Shiomi, K., Omura, S.
-
Journal Title
Journal of Biochemistry
Volume: 146
Pages: 263-271
Peer Reviewed
-
-
-
-
-
-
-
-
