2011 Fiscal Year Final Research Report
Exploration of new antitoxic compounds neutralizing ciguatera fish poisoning from some southern medicinal plants
| Project/Area Number |
21550161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kagoshima University |
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Principal Investigator |
HAMADA Toshiyuki 鹿児島大学, 大学院・理工学研究科, 准教授 (40321799)
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| Project Period (FY) |
2009 – 2011
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| Keywords | シガテラ毒解毒活性 / 化学構造 / NMR(核磁気共鳴)法 / 薬用植物 |
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| Research Abstract |
Ciguatera fish poisoning(CFP) is an ichthyosarcotoxism caused by the consumption of tropical and subtropical coral fish contaminated with toxic polyether compounds, ciguatoxins(CTXs) and maitotoxin(MTX). Garrec et al. have reported that the extracts of some southern medicinal plants, traditionally used to treat CFP, to prevent in vitro neurotoxicity produced by CTX or brevetoxin(BTX). Here, we studied new CFP antitoxic compounds isolated from verious southern medicinal plants by using in vitro neurotoxicity assay.
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