Assessment of bone biology using 3-D structured bone substitute manufactured by rapid prototyping technology

2011 Fiscal Year Final Research Report

• Project/Area Number: 21560720
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Structural/Functional materials
• Research Institution: Kyoto University
• Principal Investigator: FUJIBAYASHI Shunsuke 京都大学, 医学研究科, 助教 (30362502)
• Co-Investigator(Renkei-kenkyūsha): ADACHI Taiji 京都大学, 再生医科学研究所, 教授 (40243323)
• Project Period (FY): 2009 – 2011
• Keywords: 生体内吸収材料 / 三次元構造 / 構造解析 / 経時的変化 / 熱溶融積層法

Research Abstract

3-D structured bone substitute was manufactured by rapid prototyping technology. Optimal 3-D structure of biomaterial for both osteoconduction and osteoinduction was assessed using animal model. The results of this study revealed that 1200-micron size pore was suitable for osteoconduction and 500-micron size pore was suitable for osteoinduction. And submicron-size surface structure was also important for bone ingrowth.

Research Products

• [Journal Article] Osteoinduction of porous Ti implants with channel structure fabricated by selective laser melting (2011)
  • Author(s): Fukuda A, Takemoto M, Saito T, Fujibayashi S, Neo M, Pattanayak DK, Matsushita T, Sasaki K, Nishida N, Kokubo T, Nakamura T.
  • Journal Title: Acta Biomater Pages: 2327-36
  • DOI: DOI:10.1016/j.actbio.2011.01.037
  • Peer Reviewed
• [Journal Article] Bioactive Ti Metal Analogous to Human Cancellous Bone : Fabrication by Selective Laser Melting and Chemical Treatments (2011)
  • Author(s): Pattanayak DK, Fukuda A, Matsushita T, Takemoto M, Fujibayashi S, Sasaki K, Nishida N, Nakamura T, Kokubo T
  • Journal Title: Acta Biomater Pages: 1398-406
  • DOI: DOI:10.1016/j.actbio.2010.09.034
  • Peer Reviewed
• [Presentation] Rapid prototypingで作製した生体活性処理レンコン状チタン材料の各孔におけるbone ingrowth評価 (2009)
  • Author(s): 福田明伸、藤林俊介、他
  • Organizer: 第31回日本バイオマテリアル学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-16
• [Presentation] Fujibayashi Set al : Bone Ingrowth into Pores of Lotus-type Bioactive Titanium Fabricated Using Rapid Prototyping (2009)
  • Author(s): Fukuda A
  • Organizer: Bioceramcs
  • Place of Presentation: Daegu
  • Year and Date: 2009-10-27
• [Presentation] Fujibayashi Set al : Development of porous bioactive titanium by rapid prototyping (2009)
  • Author(s): Fukuda A
  • Organizer: 22nd European Conference on Biomaterials
  • Place of Presentation: LAUSANNE
  • Year and Date: 2009-09-09