2011 Fiscal Year Final Research Report
Development of Novel Vaccine Using Hybrid Liposomes for Cancer Therapy
| Project/Area Number |
21560813
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Sojo University |
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Principal Investigator |
GOTO Koichi 崇城大学, 生物生命学部, 教授 (30279377)
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| Co-Investigator(Kenkyū-buntansha) |
UEOKA Ryuichi 崇城大学, 生物生命学部, 教授 (70099076)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 免疫学 / 癌 / リポソーム / ワクチン / T細胞 |
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| Research Abstract |
The immunotherapeutic effects of hybrid liposomes(HL-MUC-1/mB7-1) composed of phospholipids(DMPC) and nonionic surfactants(Tween 80) including synthetic MUC-1 antigen peptides and recombinant mB7-1 proteins were examined. In vivo experiments, the prolonged survival was observed in mouse models with breast cancer cells after the treatment of HL-MUC1/mB7-1.The results suggested that HL-MUC1/mB7-1 could have the possibility of novel liposome vaccine for cancer therapy.
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