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2011 Fiscal Year Final Research Report

Cell and signal mechanisms that support tissue regeneration in fish

Research Project

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Project/Area Number 21570004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Genetics/Genome dynamics
Research InstitutionTokyo Institute of Technology

Principal Investigator

KAWAKAMI Atsushi  東京工業大学, 大学院・生命理工学研究科, 准教授 (00221896)

Project Period (FY) 2009 – 2011
Keywordsモデル生物 / 小型魚類における組織再生 / ゼブラフィッシュ / トランスジェニ / Junb / JNK
Research Abstract

To clarify the tissue homeostasis mechanism of multicellular organisms, we analyzed the regeneration processes of adult and larval zebrafish tissues and obtained the following results.
1. The signaling pathway involving the Junb, Junbl and JNK has an essential role in regeneration.
2. To reveal the origin and fate of regenerating cells, we generated transgenic lines for cell fate tracing and cell ablation.
3. From the analysis of regeneration defective zebrafish mutant, we showed that a factor derived from the hematopoietic tissues is necessary for the survival of regenerating cells.

  • Research Products

    (19 results)

All 2012 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] Filamin C plays an essential role in the maintenance of the structural integrity of cardiac and skeletal muscles, revealed by the medaka mutant zacro2012

    • Author(s)
      Fujita, M., Mitsuhashi, H., Isogai, S., Nakata, T., Kawakami, A., Nonaka, I., Noguchi, S., Hayashi, Y. K., Nishino, I. and Kudo, A
    • Journal Title

      Developmental Biology

      Volume: 361 Pages: 79-89

    • Peer Reviewed
  • [Journal Article] Mature and Juvenile Tissue Models of Regeneration in Small Fish Species2011

    • Author(s)
      Yoshinari, N. and Kawakami, A
    • Journal Title

      Biological Bulletin

      Volume: 221 Pages: 62-78

    • Peer Reviewed
  • [Journal Article] Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebra fish2010

    • Author(s)
      Ishida, T., Nakajima, T., Kudo, A. and Kawakami, A
    • Journal Title

      Developmental Biology

      Volume: 340 Pages: 468-479

  • [Journal Article] Epigenetic control mechanism of cardiomyocyte production in response to a stress during the medaka heart development2010

    • Author(s)
      Taneda, Y., Konno, S., Makino, S., Fukuda, K., Imai, Y., Kudo, A. and Kawakami, A.
    • Journal Title

      Developmental Biology

      Volume: 340 Pages: 30-40

  • [Journal Article] Stem cell system in tissue regeneration in fish2010

    • Author(s)
      Kawakami, A
    • Journal Title

      Development Growth & Differentiation

      Volume: 52 Pages: 77-87

    • Peer Reviewed
  • [Journal Article] Gene expression and functional analysis of zebra fish larval fin fold regeneration2009

    • Author(s)
      Yoshinari, N., Ishida, T., Kudo, A., and Kawakami, A
    • Journal Title

      Developmental Biology

      Volume: 325 Pages: 71-81

  • [Presentation] Amechanism that controls blastema cell proliferation and survival during fin fold regeneration2011

    • Author(s)
      Tomoya Hasegawa, Teruhiro Nakajima, Takashi Ishida, Atsushi Kawakami.
    • Organizer
      The21st CDB Meeting "From Regeneration Biology to Regenerative Medicine(I)"
    • Place of Presentation
      RIKEN CDB, Kobe
    • Year and Date
      20111124-25
  • [Presentation] Towards understanding tissue regeneration and homeostasis mechanism using fish regeneration models2011

    • Author(s)
      Atsushi Kawakami, Natsumi Horita, Tomomi Kushida, Kazunori Ando, EmikoMurase, Nozomi Yoshianri, Masato Kinoshita, Genbu Abe, Koichi Kawakami, and Tohru Ishitani
    • Organizer
      The21st CDB Meeting "From Regeneration Biology to Regenerative Medicine(I)"
    • Place of Presentation
      RIKEN CDB, Kobe
    • Year and Date
      20111124-25
  • [Presentation] 魚類における2つのフィブロネクチンの再生における働きの解析2011

    • Author(s)
      村瀬瑛美子、工藤明、川上厚志
    • Organizer
      第34回日本分子生物学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
  • [Presentation] Cell ablation analysis in the regenerating zebrafish fin : Generation of transgenic zebrafish and the cell ablation using the prodrug and nitroreductaseゼブラフィッシュ再生ひれにおける細胞除去:トランスジェニック作製とプロドラッグ、ニトロリダクターゼを用いた細胞除去2011

    • Author(s)
      安藤和則、吉成望、工藤明、川上厚志
    • Organizer
      第44回日本発生生物学会大会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-05-20
  • [Presentation] Amechanism that controls blastema cell proliferation and survival during zebrafish fin fold regenerationゼブラフィッシュ膜ひれ再生における再生芽の増殖と生存の調節2011

    • Author(s)
      川上厚志、中島輝弘、石田高志、工藤明
    • Organizer
      第44回日本発生生物学会大会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-05-19
  • [Presentation] ユビキタスに蛍光タンパクを発現する新たなゼブラフィッシュ系統2010

    • Author(s)
      吉成望、工藤明、川上厚志
    • Organizer
      第10回小型魚類研究会
    • Place of Presentation
      埼玉
    • Year and Date
      2010-09-18
  • [Presentation] 心筋・骨格筋に異常を示すメダカ変異体zacroの解析2010

    • Author(s)
      三橋弘明、藤田深里、安田裕隆、林由起子、野口悟、埜中征哉、川上厚志、工藤明、西野一三
    • Organizer
      第10回小型魚類研究会
    • Place of Presentation
      埼玉
    • Year and Date
      2010-09-18
  • [Presentation] Checkpoint for fast proliferating blastema cells during finfold regeneration,再生細胞の早い細胞増殖を検問するチェックポイントメカニズム2010

    • Author(s)
      Teruhiro Nakajima, Akira Kudo, and Atsushi Kawakami
    • Organizer
      第43回日本発生生物学会大会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-21
  • [Presentation] Cell lineage analysis of fish fin blastema for their potential producing multiple cell types during regeneration再生芽細胞の多分化能力を検証するための、魚類鰭の再生組織における細胞系譜の解析,再生細胞の早い細胞増殖を検問するチェックポイントメカニズム2010

    • Author(s)
      Nozomi Yoshinari, Akira Kudo, OAtsushiKawakami
    • Organizer
      第43回日本発生生物学会大会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-21
  • [Presentation] ゼブラフィッシュにおける再生芽細胞の分化多能性の検証2009

    • Author(s)
      吉成望、工藤明、川上厚志
    • Organizer
      第31回日本分子生物学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
  • [Presentation] Indispensable role of Junb/Jnk signaling in regeneration : regeneration can be demarcated from wound healing by the dependence on Junb/Jnk signaling2009

    • Author(s)
      Takashi Ishida, Akira Kudo, and OAtsushi Kawakami
    • Organizer
      第41回日本発生生物学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-05-30
  • [Presentation] cloche mutation causes the blastema apoptosis during the zebrafish fin fold regeneration2009

    • Author(s)
      Teruhiro Nakajima, Takashi Ishida, Akira Kudo, Atsushi Kawakami
    • Organizer
      第41回日本発生生物学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-05-30
  • [Remarks]

    • URL

      http://www.kudo.bio.titech.ac.jp/Index2.htm

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Published: 2013-07-31  

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