2011 Fiscal Year Final Research Report
Molecular mechanisms of the redox regulation of translation and the response of photosynthesis to environmental changes
| Project/Area Number |
21570033
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Saitama University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HISABORI Toru 東京工業大学, 資源化学研究所, 教授 (40181094)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 色素体機能 / 光合成 |
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| Research Abstract |
Elongation factor G, a key protein in translation elongation, was inactivated via the formation of an intramolecular disulfide bond between two specific cysteine residues under oxidative conditions in the cyanobacterium Synechocystissp. PCC 6803. Reduction of the disulfide bond by thioredoxin resulted in the reactivation of EF-G, suggesting that translation might be regulated by the reducing power derived from the photosynthetic electron transport. Replacement of the target cysteine residue of EF-G by serine in Synechocystiscells protected photosystem II from photoinhibition.
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Research Products
(33 results)
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[Journal Article] Regulation of translation by the redox state of elongation factor G in the cyanobacterium Synechocystis2009
Author(s)
Kojima, K., Motohashi, K., Morota, T., Oshita, M., Hisabori, T., Hayashi, H., Nishiyama, Y.
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Journal Title
J. Biol. Chem.
Volume: 284(28)
Pages: 18685-18691
Peer Reviewed
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