2011 Fiscal Year Final Research Report
Diurnal rhythm of the ridge formation in regenerating scale and its regulation by clock genes and melatonin
| Project/Area Number |
21570062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Toru 東北大学, 農学研究科, 教授 (70344330)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 再生鱗 / 骨芽細胞 / 隆起線 / 概日リズム / 時計遺伝子 / メラトニン |
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| Research Abstract |
In the hard tissue the presence of the incremental line formed as a unit about a day has been known than before. The formation mechanism of the diurnal incremental line has not been clarified, then, in this study, the experiment was conducted to clarify the mechanism using a regenerating scale of the goldfish. In the expression of osteoblast-specific genes during spontaneous scale regeneration, it shared similarities in gene expression with mammalian intramembranous bone regeneration. The regenerating scales showed that the ridges(incremental lines) are formed in the outer one on each day. In the expression of clock genes in regenerating scale, a clear circadian rhythm was observed in the expression of per-3 gene. Improved understanding of the ridge formation in regenerating scale will help elucidate the mechanism of formation of the diurnal incremental line in the hard tissue.
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[Journal Article] Expression of osteoblastic and osteoclastic genes during spontaneous regeneration and autotransplantation of goldfish scale : Anew tool to study intramembranous boneregeneration2012
Author(s)
Thamamongood, T. A, Furuya, R., Fukuba, S., Nakamura, M., Suzuki, N. and Hattori, A.
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Journal Title
Bone
Volume: 50
Pages: 1240-1249
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[Journal Article] Parathyroid hormone 1(1-34) acts on the scales and involves calcium metabolism in goldfish2011
Author(s)
Suzuki, N., Danks, J. A., Maruyama, Y., Sasayama, Y., Hattori, A., (他15名)
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Journal Title
Bone
Volume: 48
Pages: 1186-1193
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[Journal Article] Osteoblast activity in the goldfish scale responds sensitively to mechanical stress2010
Author(s)
Kitamura, K., Suzuki, N., Sato, Y., Nemoto, T., Ikegame, M., Yamamoto, T., Shimizu, N., Kondo, T., Furusawa, Y., Wada, S. and Hattori, A.
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Journal Title
Comp. Biochem. Physiol.
Volume: part A 156
Pages: 357-363
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[Journal Article] Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus2010
Author(s)
Chowdhury, V. S, Yamamoto, K., Ubuka, T., Bentley, G. E., Hattori, A. and Tsutsui, K.
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Journal Title
Endocrinology
Volume: 151
Pages: 271-280
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[Journal Article] Diurnal expressions of four subtypes of melatonin receptor genes in the optictectum and retina of goldfish.2009
Author(s)
Ikegamia, T., Azuma, K., Nakamura, M., Suzuki, N., Hattori, A. and Ando, H.
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Journal Title
Comp. Biochem. Physiol.
Volume: Part A 152
Pages: 219-224
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[Journal Article] Monohydroxylated polycyclic aromatic hydrocarbons inhibit both osteoclastic and osteoblastic activities in teleost scales2009
Author(s)
Suzuki, N., Hayakawa, K., Kameda, K., Toriba, A., Tang, N., Tabata, M. J., Takada, K., Wada, S., Omori, K., Srivastav, A. K., Mishima, H. and Hattori, A.
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Journal Title
Life Sci.
Volume: 84
Pages: 482-488
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[Presentation] The relationship between the melatonin and the periodicity of incremental lines in the tooth dentin2010
Author(s)
Kitahara, M., Hattori, A., Suzuki, N., Tabata, M. J., Kakei, M., Miake, Y. and Mishima, H.
Organizer
37th European Symposium on Calcified Tissues
Place of Presentation
Glasgow
Year and Date
2010-06-26
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