2011 Fiscal Year Final Research Report
The role of cadherin switching in the differentiation of adenohypophyseal cells
| Project/Area Number |
21570067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HORIGUCHI Kotaro 自治医科大学, 医学部, 助教 (10409477)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞接着因子 / 腺下垂体 / Notchシグナリング / 細胞分化 |
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| Research Abstract |
We found in the developing rat adenohypophysis that primordial cells co-expressed E-and N-cadherins, but endocrine cells lost E-cadherin to possess only N-cadherin in the process of cell differentiation. This change of cadherin type, cadherin switching, was shown to play important roles in the regulated secretion of hormones by affecting cortical actin network and in the Notch signaling-mediated proliferation/differentiation of progenitor cells through differential cell adhesion.
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