2011 Fiscal Year Final Research Report
Development of the pituitary research in terms of regulation of its function in the amphibian as a model
Project/Area Number |
21570071
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Morphology/Structure
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Research Institution | Waseda University |
Principal Investigator |
KIKUYAMA Sakae 早稲田大学, 教育・総合科学学術院, 名誉教授 (20063638)
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Co-Investigator(Kenkyū-buntansha) |
HASUNUMA Itaru 東邦大学, 理学部, 講師 (40434261)
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Project Period (FY) |
2009 – 2011
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Keywords | 視床下部因子 / 脳下垂体 / 両生類 / 変態 / 比較内分泌学 |
Research Abstract |
We have demonstrated that in amphibians, mammalian homologue of corticotropin-releasing factor(CRF) is the major factor that enhances the release of thyroid-stimulating hormone(TSH) from the pituitary. This prompted us to determine the role of some other hypothalamic factors in terms of regulation of the release of pituitary hormones, focusing on their activities and receptors. Thus, we concluded that arginine vasotocin is the major factor that stimulates the release of adrenocorticotropic hormone(ACTH), and that thyrotropin. releasing hormone does not act as a TSH-releasing factor but as a prolactin-releasing factor. The discrepancy in the role of hypothalamic factors between amphibians and mammals is discussed in relation to metamorphosis and thermoregulation.
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Research Products
(43 results)
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[Journal Article] Acute stress increases the synthesis of 7α-hydroxypregnenolone, a new key neurosteroid stimulating locomotor activity, through corticosterone action in newts2012
Author(s)
Haraguchi S, Koyama T, Hasunuma I, Okuyama S, Ubuka T, Kikuyama S, Do Rego JL, Vaudry H, Tsutsui K.
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Journal Title
Endocrinology
Volume: 153
Pages: 794-805
Peer Reviewed
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