2011 Fiscal Year Final Research Report
Studies on molecular mechanisms underlying the insect olfactory associative learning
| Project/Area Number |
21570074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tokyo Gakugei University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 昆虫 / 連合学習 / キノコ体 / ケニオン細胞 / イオンチャネル / 受容体 |
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| Research Abstract |
To understand the molecular basis of CS-US association, first I investigated the receptors and ionic channels expressed in Kenyon cells and second their regulation by neurotransmitter substances which convey US and CS signals. The present study mainly focused on the modulation of Na^+-activated K^+and voltage-activated Ca^<2+> channels induced by muscarinic receptor activation and its possible downstream pathway involving NOS/NO/cGMP/PKG signaling. The present results indicate that muscarinic type of M_1 receptor activation decreases the open probability(NPo) of K_<Na> channels and increases NPo of Ca^<2+> channels via the sequential activation of PLC, Ca/CAM complex and NOS/NO/cGMP/PKG signaling cascades in Kenyon cells isolated from the mushroom body of the cricket Gryllus bimaculatus.
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