2011 Fiscal Year Final Research Report
Analysis on the electron transfer cascade coupled by Vanabin2
| Project/Area Number |
21570077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UEKI Tatsuya 広島大学, 大学院・理学研究科, 准教授 (10274705)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ホヤ / バナジウム / 酸化還元 / グルタチオン / 金属結合タンパク質 / システイン |
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| Research Abstract |
Ascidians belonging to the class Ascidiidae accumulate a transition metal vanadium(V) ions up to 350 mM, and reduce most of the accumulated V. Recently we found that Vanabin2 can act as a V(V)-reductase in the presence of glutathione(GSH). In this study, we identified Trx/ Grx genes in ascidians and examined the redox cascade composed of NADPH, glutathione reductase(GR), GSH, Trx/ Grx, and Vanabin and found that this redox cascade functions as coupled with SH-SS exchange reactions.
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