2011 Fiscal Year Final Research Report
Roles of AAA peroxins in peroxisome biogenesis
| Project/Area Number |
21570116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIKI Yukio 九州大学, 大学院・理学研究院, 教授 (70261237)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞小器官 / ペルオキシソーム |
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| Research Abstract |
The aim of this study is to investigate the molecular mechanism of peroxisome biogenesis. Pexl4p is a central component of the peroxisomal protein import machinery, in which the conserved Nterminal domain mediates dynamic interactions with Pex5p. We reported the crystal structure of the conserved Nterminal domain of Pexl4p with a three-helix bundle. Furthermore, AAA peroxins are most likely regulated in their peroxisomal localization onto Pex26p via conformational changes by the ATPase cycle, and modulatethe interaction between Pex26p and Pexl4p on peroxisome membrane.
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Research Products
(12 results)
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[Journal Article] New insights into dynamic and functional assembly of the AAA peroxins, Pexlp and Pex6p, and their membrane receptor Pex26p in shuttling of PTS1receptor Pex5p in peroxisome biogenesis2012
Author(s)
Fujiki, Y., Nashiro, C., Miyata, N., Tamura, S., and Okumoto, K.
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Journal Title
Biophys. Acta
Volume: 1823
Pages: 145-149
DOI
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