2011 Fiscal Year Final Research Report
Development of highly selective inhibitors against individual MMPs
| Project/Area Number |
21570118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
HIGASHI Shouichi 横浜市立大学, 大学院・生命ナノシステム科学研究科, 准教授 (10275076)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子認識及び相互作用 |
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| Research Abstract |
(1) We determined the crystal structure of the catalytic domain of MMP-2 in complex with decapeptide inhibitor APP-IP, and clarified its mode of the MMP-2-selective inhibition.(2) We designed a highly selective and strong inhibitor against MMP-2 by combining the MMP-2-selective peptide inhibitor APP-IP and physiological MMPs inhibitor TIMP-2.(3) We clarified the mechanism of the cholesterol sulfate-mediated alteration of the substrate preference of MMP-7 ; clarification of the mechanism provides the clue to develop MMP-7-selective inhibitors.
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