2011 Fiscal Year Final Research Report
Molecular basis of the regulation of adipogenesis by lipid mediators
| Project/Area Number |
21570151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
FUJIMORI Ko 大阪薬科大学, 薬学部, 講師 (70425453)
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| Co-Investigator(Kenkyū-buntansha) |
ARITAKE Kosuke 大阪バイオサイエンス研究所, 分子行動生物学部門, 研究員 (70390804)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脂質メディエーター / プロスタグランジン / 肥満 / 分化制御 |
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| Research Abstract |
Prostaglandin(PG) E_2 and PGF_<2α>, members of lipid mediators, are synthesized by microsomal PGE synthase-1 and aldo-keto reductase 1B3, respectively, in adipocytes, and synergistically suppress the progression of the early phase of adipogenesis. Moreover, these PGE_2 and PGF_<2α> enhance the expression of cyclooxygenase-2 gene through their EP4 and FP receptors. We also found thatΔ^<12>-PGJ_2, one of PGD_2 metabolites, activates the adipogenesis.
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