2011 Fiscal Year Final Research Report
Molecular Mechanism of re-isomerization ofretinal in visual cycle
Project/Area Number |
21570174
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biophysics
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Research Institution | Tokushima Bunri University |
Principal Investigator |
TSUDA Motoyuki 徳島文理大学, 香川薬学部, 客員教授 (60045458)
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Co-Investigator(Renkei-kenkyūsha) |
TERAKITA Akihisa 大阪市立大学, 理学研究科, 教授 (30212062)
KUSAKABE Takehiro 甲南大学, 理工学部, 教授 (40280862)
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Project Period (FY) |
2009 – 2011
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Keywords | 視覚サイクル / レチナール |
Research Abstract |
Absorption of a photon by visual pigments induces isomerization of 11-cis-retinaldehyde(RAL) chromophore to all-trans-RAL. Here we comparevisual retinoid cycles between different photoreceptors of vertebrates as well as invertebrates. The visual cycle systems in ascidians, the closest living relatives of vertebrates, show an intermediate state between vertebrates and non-chordate invertebrates. The ascidian larva may use retinochrome-like opsin as the major isomerase retinal but RPE65 in asidinan did not isomerase retinal. These results are very interesting in the evolutional standpoints.
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[Journal Article] Tube formation by complexcellular processes in Ciona intestinalis notochord2009
Author(s)
Dong, B., Horie, T., Denker, E., Kusakabe, K., Tsuda, M., Smith, W., Jiang, D.
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Journal Title
Dev. Biol
Volume: 330(2)
Pages: 237-249
Peer Reviewed
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