2011 Fiscal Year Final Research Report
Mechanisms of Epigenetic Inheritance in Condensed Mitotic Chromosomes
| Project/Area Number |
21570177
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 染色体構築 / 機能 |
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| Research Abstract |
During the mitotic phase of the mammalian cell cycle, DNA is tightly packaged in condensed chromosomes, transcription factors are displaced from DNA, and all genes are silenced. Accordingly, the condensed condition of mitotic chromosomes has been assumed to inhibit all kinds of DNA metabolism. In the present study, DNA repair activity in mitotic cells was investigated. Unexpectedly, it was observed that some modes of DNA repair were functional in mitotic cells, suggesting that the proteins involved in these DNA repair modes could function in condensed mitotic chromosomes.
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[Journal Article] Effects of calorie restriction on the age-dependent accumulation of mutations in the small intestine of lacZ-transgenic mice2011
Author(s)
He D, Uehara Y, Furuya M, Ikehata H, Komura J, Yamauchi K, Kakinuma S, Shang Y, Shimada Y, Ootsuyama A, Norimura T, Ono T
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Journal Title
Mech Age Dev
Volume: 132
Pages: 117-122
Peer Reviewed
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