2011 Fiscal Year Final Research Report
Functional elucidation of IRBIT, a master regulator in the central nervous system
| Project/Area Number |
21570190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Showa Pharmaceutical University (2011)
The Institute of Physical and Chemical Research (2009-2010) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | IRBIT / 多重リン酸化領域 / 細胞外環境応答 |
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| Research Abstract |
IRBIT is highly expressed in the glial processes facing and/or ensheathing synaptic clefts. IRBIT interacts with both IP3 receptor and NBC1 in its phosphorylation dependent manner, and modulates their functions. The phosphorylated residues on IRBIT which binds to IP3R with high affinity were revealed to differ from those of IRBIT which binds to NBC1.
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Research Products
(4 results)
