2011 Fiscal Year Final Research Report
Genome side screening of autophagy to elucidate its regulation
Project/Area Number |
21570197
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cell biology
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Research Institution | Osaka University |
Principal Investigator |
NODA Takeshi 大阪大学, 生命機能研究科, 准教授 (00290908)
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Project Period (FY) |
2009 – 2011
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Keywords | オートファジー / 酵母 / スクリーニング |
Research Abstract |
Autophagy is intracellular bulk degradation system, but its regulatory mechanism is largely unknown. In this study, we succeeded in introducing ALP system, which enables quantitation of autophagy activity, into the genome wide yeast mutant collection. We measured autophagic activity under nitrogen starvation in large scale and found that several intriguing factors are directly associated with autophagy regulation. Thus we advanced understanding the mechanism of autophagy regulation.
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[Journal Article] Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus2011
Author(s)
Taguwa, S., Kambara, H., Fujita, N., Noda, T., Yoshimori, T., Koike, K., Moriishi, K., Matsuura, Y.*
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Journal Title
URL
Peer Reviewed
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[Journal Article] The LC3 recruitment mechanism is separate from Atg9L1 dependent membrane formation in the autophagic response against Salmonella2011
Author(s)
Kageyama, S., Omori, H., Saitoh, T., Sone, T., Guan, J. L., Akira, S., Imamoto, F., Noda, T.*, Yoshimori, T.*
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Journal Title
Mol Biol Cell
Volume: 22
Pages: 2290-2300
Peer Reviewed
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[Journal Article] Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy2010
Author(s)
Taguchi-Atarashi, N., Hamasaki, M., Matsunaga, K., Omori, H., Ktistakis, N. T., Yoshimori, T., Noda, T.*
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Journal Title
Traffic
Volume: 11
Pages: 468-478
Peer Reviewed
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[Journal Article] Rubicon and PLEKHM1 negatively regulate the endocytic/ autophagic pathway via a novel Rab7-binding domain2010
Author(s)
Tabata, K., Matsunaga, K., Sakane, A., Sasaki, T., Noda, T., Yoshimori, T.*
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Journal Title
Mol Biol Cell
Volume: 21
Pages: 4162-4172
Peer Reviewed
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[Journal Article] Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L2010
Author(s)
Matsunaga, K., Morita, E., Saitoh, T., Akira, S., Ktistakis, N. T., Izumi, T., Noda, T.*, Yoshimori, T.*
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Journal Title
J Cell Biol
Volume: 190
Pages: 511-521
Peer Reviewed
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[Journal Article] Electron tomography reveals the endoplasmic reticulum as a membrane source for autophagosome formation2010
Author(s)
Hayashi-Nishino, M., Fujita, N., Noda, T., Yamaguchi, A., Yoshimori, T. & Yamamoto, A.*
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Journal Title
Autophagy
Volume: 6
Pages: 301-303
Peer Reviewed
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[Presentation] Autophagy requires endoplasmic reticulum-targeting of the PI3-kinase complex via Atg14L2010
Author(s)
Matsunaga, K., , Morita, E., Saitoh, T., Akira, S., Ktistakis N. T., Izumi, T., Noda, T., Yoshimori, T
Organizer
EMBO Conference, Towards a comprehensive understanding of endoplasmic reticulum functions
Place of Presentation
Girona, Spain
Year and Date
2010-10-04
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[Presentation] Recruitment of LC3 is separable from the membrane generation system in autophagy against Salmonella.2010
Author(s)
Kageyama, S., Omori, H., Saitoh, T., Sone, T., Akira S., Imamoto, F., Noda, T., Yoshimori, T.
Organizer
The 10^<th> Awaji International Forum on Infection and Immunity(Poster pick up)
Place of Presentation
淡路島
Year and Date
2010-09-09
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