2011 Fiscal Year Final Research Report
Analysis of mechanisms to regulate oxidative stress response by glyceraldehyde-3-phosphate dehydrogenase
| Project/Area Number |
21570198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
MORIGASAKI Susumu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 研究員 (90242487)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞内情報伝達 / タンパク質複合体 / target of rapamycin |
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| Research Abstract |
As environmental conditions are always fluctuating, it is most important function for organisms to sense the changes and protect themselves. I, in this research, biochemically analyzed two signal transduction pathways that control stress resistance or proliferation/growth. Moreover, I elucidated function of a glycolytic enzyme GAPDH on the pathways. In conclusion, GAPDH has functions as a sensor of oxidative stress and a master regulator of adaptation to the stress conditions, in addition to the classical function.
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