2011 Fiscal Year Final Research Report
Roles of GBF1 in cell migration of neutrophil
| Project/Area Number |
21570201
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
MAZAKI Yuichi 熊本大学, 大学院・先導機構, 特任助教 (60311304)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 細胞骨格・運動 / 極性形成 |
|---|
| Research Abstract |
It is known that neutrophils rapidly migrate into the infection sites of invading pathogens, although the molecular mechanism remains largely unknown. In this study, to resolve the molecular mechanism of cell migration in neutrophil, we examined the activation mechanism and roles of GBF1, intercellular trafficking associated protein, in cell migration. We found that GBF1 is activated by PI(3, 4, 5) P_3, and that GBF1 is involved in subcellular localization of ARF1 and GIT2 during cell migration.
|
