2011 Fiscal Year Final Research Report
Role of endoplasmic reticulum stress signaling in terminal differentiation of myoblasts
| Project/Area Number |
21570210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MORISHIMA Nobuhiro 独立行政法人理化学研究所, 中野生体膜研究室, 専任研究員 (40182232)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞分化 / アポトーシス / 筋芽細胞 / 小胞体ストレス / カスパーゼ / ATF6 / WBP1 / Mcl-1 |
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| Research Abstract |
Overexpression of active ATF6 induces apoptosis in myoblast cells. ATF6 up-regulated WW domain binding protein 1(WBP1), which was found to be proapoptotic. Overexpression of active ATF6 or WBP1 caused a specific decrease in an antiapoptotic protein, myeloid cell leukemia sequence 1(Mcl-1). Cells treated with ER stressors underwent apoptosis and exhibited an up-regulation of WBP1 and decreased Mcl-1.These results suggest that ATF6 mediates apoptosis via specific reduction of Mcl-1 levels through the up-regulation of WBP1.
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