2011 Fiscal Year Final Research Report
Molecular mechanism of centromere clustering at SPB in the fission yeast
| Project/Area Number |
21570212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | National Institute of Information and Communications Technology |
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Principal Investigator |
MAEKAWA Hiromi 独立行政法人情報通信研究機構, 未来ICT研究所・バイオICT研究室, 専攻研究員 (80399683)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 遺伝子 / シグナル伝達 / 発現制御 / 蛋白質 |
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| Research Abstract |
We demonstrated that N-terminal domain of Sad1, an SPB component in S. pombe, is required for efficient re-accumulation of kinetochore components when cells return to mitotic cycle from meiotic cycle and thereby facilitate re-establishment of the centromere clustering at SPB. We also showed that inner nuclear membrane protein Ima1 has no apparent role in the centromere-SPB interaction, but instead is required for the formation and maintenance of nuclear membrane structure and the cell cycle progression.
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