2011 Fiscal Year Final Research Report
Towards understanding mechanisms of an organizer development in social amoeba, Dictyostelium discoideum
| Project/Area Number |
21570214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 発生・分化 / オーガナイザー / 発現制御 / シグナル伝達 / 細胞運動 |
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| Research Abstract |
In the model organism, Dictyostelium discoideum, the most anterior part, slug tip, behaves as an organizer because when transplanted to another slug, it results in forming a second slug. Here I analyzed the anatomy of the slug tip in detail using gene markers including a newly identified one by this study, and revealed that the slug tip, the pstA region, consists of at least two prestalk subtypes (pstA1 and pstA2). By DNA affinity purification, an orthologue of the Myelin-gene regulatory transcription factor A (MrfA) was identified as a key factor in pstA2 cell differentiation. The characterization of mrfA suggested possible functions of the gene in organizer function in lower eukaryotes.
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[Remarks] (1)Hiroshi Senoo and Masashi Fukuzawa. Epigenetic differentiation of prestalk cells in growing Dictyostelium cells.奈良先端技術大学院大学セミナー(奈良)、2011.4.6.
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[Remarks] (2)福澤雅志:細胞性粘菌のオーガナイザー形成と細胞分化にかかわる遺伝子の同定.基礎生物学研究所共同利用研究報告書13:125-126,2010.
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[Remarks] (3)福澤雅志:モデル生物「細胞性粘菌」の生物学.出前講義 苫小牧東高校、2010.12.8.
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[Remarks] (4)福澤雅志:モデル生物「細胞性粘菌」の生物学.弘前大学ドリーム講座黒石高校、2009.7.28.
