2012 Fiscal Year Final Research Report
In vivo imaging of embryonic cell death in the new model animal and its molecular analysis
| Project/Area Number |
21570223
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
UENO Naoto 基礎生物学研究所, 形態形成研究部門, 教授 (40221105)
|
|---|
| Project Period (FY) |
2009 – 2012
|
| Keywords | 発生遺伝 / 細胞死 |
|---|
| Research Abstract |
FADD is an adaptor protein that transmits apoptotic signals in the cell. In this study, we have shown that FADD has multiple functions in Xenopus embryos; it plays roles in heart formation as well as apoptosis. We also established a transgenic frog line expressing a biosensor, which is suitable for detecting dying cells, and observed the change of the biosensor in developing embryos when apoptosis was induced
|
