2011 Fiscal Year Final Research Report
Study for a novel mechanism of developmental regulation via nucleocytoplasmic transport
| Project/Area Number |
21570224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 核-細胞質間分子輸送 / 初期胚発生 / importinα / 情報伝達制御 |
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| Research Abstract |
We have previously found that the nucleocytoplasmic transport system plays an important role for differentiation of mouse embryonic stem cells. The goal of this research is to investigate the role of transport receptors during embryogenesis. We found that transport receptor importin. family members were differentially expressed during mouse embryogenesis. We also found that one member of importin. family has a specific activity to inhibit the nuclear transport of certain transcription factor. Therefore, it is becoming clear that the nucleocytoplasmic transport machinery is involved in cell differentiation and organism development.
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