2011 Fiscal Year Final Research Report
Characterization of maternal factor Mamo which is associated with the regulation of germline development and meiosis in Drosophila
| Project/Area Number |
21570233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Konan University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Satoru 大学共同利用機関法人自然科学研究機構, 教授 (90225508)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生殖細胞 |
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| Research Abstract |
Maternal factor Mamo is autonomously required in pole cells to produce functional gametes in Drosophila. Mamo protein is predicted to regulate the expression of downstream genes as a chromatin regulator, since Mamo shares sequence homology with chromatin regulators that contain both a BTB/POZ domain and C_2H_2 zinc finger motifs. Using in vitro assays and genetic analysis, we show that Mamo protein directly binds to specific DNA consensus sequences in target downstream genes in order to regulate their expression.
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