2011 Fiscal Year Final Research Report
Functional analysis of GGDEF/EAL proteins that control the stability of small RNA
| Project/Area Number |
21580088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
TONY Romeo フロリダ大学, 微生物・細胞科学, 教授
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| Project Period (FY) |
2009 – 2011
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| Keywords | 大腸菌 / バイオフィルム / GGDEFドメイン / EALドメイン / c-di-GMP / Csrシステム / small RNA |
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| Research Abstract |
To elucidate the mechanism of bacterial biofilm formation control, we analyzed the function of the GGDEF/EAL proteins in bacteria. GGDEF/EAL protein CsrD was not involved in c-di-GMP metabolism and altered the activity in each growth phase and controlled biofilm formation by regulating the stability of small RNA. On the other hand, YliF(GGDEF protein) and YliE(EAL protein) controlled biofilm formation by regulating the synthesis and degradation of c-di-GMP.
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Research Products
(7 results)
