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2011 Fiscal Year Final Research Report

Characterization of mouse bile acid sulfotransferase

Research Project

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Project/Area Number 21580114
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied biochemistry
Research InstitutionUniversity of Miyazaki

Principal Investigator

SAKAKIBARA Yoichi  宮崎大学, 農学部, 准教授 (90295197)

Co-Investigator(Kenkyū-buntansha) SUIKO Masahito  宮崎大学, 農学部, 教授 (00128357)
Project Period (FY) 2009 – 2011
Keywords硫酸転移酵素 / 硫酸化 / 胆汁酸 / 解毒代謝
Research Abstract

Recombinant mouse SULT4A1 was expressed in E. coli. This SULT can catalyze the sulfation of 7-hydroxy group of bile acids. The site specific mutagenesis experiments show the Leu99 and His48 are important amino acid residues for substrate recognition and enzyme catalysis.

  • Research Products

    (22 results)

All 2012 2011 2010 2009

All Journal Article (19 results) (of which Peer Reviewed: 17 results) Presentation (3 results)

  • [Journal Article] Identification and characterization of zebrafish SULT1 ST9, SULT3 ST4, and SULT3 ST52012

    • Author(s)
      Mohammed, Y. I., Kurogi, K., Shaban, A. A., Xu, Z., Liu, M.-Y., Williams, F. E., Sakakibara, Y., Suiko, M., Bhuiyan, S., Liu, M.-C.
    • Journal Title

      Aquat. Toxicol

      Volume: 112-113 Pages: 11-18

    • Peer Reviewed
  • [Journal Article] A comparative study of the sulfation of bile acids and a bile alcohol by the Zebra danio(Danio rerio) and human cytosolic sulfotransferases(SULTs)2011

    • Author(s)
      Kurogi, K., Krasowski, M. D., Injeti, E., Liu, M.-Y., Williams, F. E., Sakakibara, Y., Suiko, M., Liu, M.-C
    • Journal Title

      J. Steroid Biochem. Mol. Biol

      Volume: 127 Pages: 307-314

    • Peer Reviewed
  • [Journal Article] Efficient approach for simultaneous estimation of the multiple health-promoting effects of foods2011

    • Author(s)
      Nagahama, K., Eto, N., Yamamori, K., Nishiyama, K., Sakakibara, Y., Iwata, T., Uchida, A., Yoshihara, I., Suiko, M
    • Journal Title

      J. Agric. Food Chem

      Volume: 59 Pages: 8575-8588

    • Peer Reviewed
  • [Journal Article] 薬物代謝と農薬の効能:特に硫酸化について2011

    • Author(s)
      橋口拓勇, 榊原陽一, 水光正仁
    • Journal Title

      日本農薬学会誌

      Volume: 36 Pages: 297-299

  • [Journal Article] Enzymatic sulfation of tocopherols and tocopherol metabolites by human cytosolic sulfotransferases2011

    • Author(s)
      Hashiguchi, T., Kurogi, K., Sakakibara, Y. Yamasaki, M., Nishiyama, K., Yasuda, S., Liu, M.-C., Suiko, M
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 75 Pages: 1951-1956

    • Peer Reviewed
  • [Journal Article] Sulfation of chlorotyrosine and nitrotyrosine by human lung endothelial and epithelial cells : Role of the human SULT1A32011

    • Author(s)
      Yasuda, S., Yasuda, T., Liu, M.-Y., Shetty, S., Idell, S., Boggaram, V., Suiko, M., Sakakibara, Y., Fu, J., Liu, M.-C
    • Journal Title

      Toxicol. Appl. Pharmacol

      Volume: 251 Pages: 104-109

    • Peer Reviewed
  • [Journal Article] Identification, characterization, and ontogenic study of a catechol O-methyltransferase from zebrafish2011

    • Author(s)
      Alazizi, A., Liu, M.-Y., Williams, F. E., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C
    • Journal Title

      Aquat. Toxicol

      Volume: 102 Pages: 18-23

    • Peer Reviewed
  • [Journal Article] Inhibitory effects of nitrative stress on the sulfation of 17beta-estradiol and 4-methoxyestradiol by human MCF 10A mammary epithelial cells2010

    • Author(s)
      Hui, Y., Yasuda, T., Yasuda, S., Liu, M.-Y., Sakakibara, Y., Suiko, M., Wall, K. A., Liu, M.-C
    • Journal Title

      Biol. Pharm. Bull

      Volume: 33 Pages: 1633-1637

    • Peer Reviewed
  • [Journal Article] Mouse cytosolic sulfotransferase SULT2B1b interacts with cytoskeletal proteins via a proline/serine-rich C-terminus2010

    • Author(s)
      Kurogi, K., Sakakibara, Y., Kamemoto, Y., Takahashi, S., Yasuda, S., Liu, M.-C., Suiko, M
    • Journal Title

      FEBS J

      Volume: 277 Pages: 3804-3811

    • Peer Reviewed
  • [Journal Article] Zebrafish as a Model for the Study of the Phase II Cytosolic Sulfotrans ferases2010

    • Author(s)
      Liu, T. A., Bhuiyan, S., Liu, M.-Y., Sugahara, T., Sakakibara, Y., Suiko, M., Yasuda, S., Kakuta, Y., Kimura, M., Williams, F. E., Liu, M.-C
    • Journal Title

      Curr. Drug Metab

      Volume: 11 Pages: 538-546

    • Peer Reviewed
  • [Journal Article] Sulfation of drug compounds by the zebrafish cytosolic sulfotrans ferases(SULTs)2010

    • Author(s)
      Kurogi, K., Dillon, J., Nasser, A., Liu, M.-Y., Williams, F. E., Sakakibara, Y., Suiko, M., Liu, M.-C
    • Journal Title

      Drug Metab. Lett

      Volume: 4 Pages: 62-68

    • Peer Reviewed
  • [Journal Article] Molecular cloning and characterization of a novel canine sulfotran sferase2010

    • Author(s)
      Kurogi, K., Sakakibara, Y., Yasuda, S., Liu, M.-C., Suiko, M
    • Journal Title

      Animal Cell Technology

      Volume: 16 Pages: 221-229

    • Peer Reviewed
  • [Journal Article] A novel hydroxysteroid-sulfating cytosolic sulfotransferase, SULT3 ST3, from zebrafish : Identification, characterization, and ontogenic study2009

    • Author(s)
      Yasuda, S., Burgess, M., Yasuda, T., Liu, M.-Y., Bhuiyan, S., Williams, F. E., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C
    • Journal Title

      Drug Metab. Lett

      Volume: 3 Pages: 217-227

    • Peer Reviewed
  • [Journal Article] On the similar spatial arrangement of active site residues in PAPS-dependent and phenolic sulfate-utilizing sulfotransferases2009

    • Author(s)
      Teramoto, T., Adachi, R., Sakakibara, Y., Liu, M.-C., Suiko, M., Kimura, M., Kakuta, Y
    • Journal Title

      FEBS Lett

      Volume: 583 Pages: 3091-3094

    • Peer Reviewed
  • [Journal Article] 疾病環境における硫酸転移酵素とそのはたらき2009

    • Author(s)
      安田伸, 榊原陽一, 水光正仁
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 第67巻 Pages: 19-23

  • [Journal Article] Concerted action of the cytosolic sulfotransferase, SULT1A3, and catechol-O-methyltransferase in the metabolism of dopamine in SK-N-MC human neuroblastoma cells2009

    • Author(s)
      Yasuda, S., Yasuda, T., Hui, Y., Liu, M.-Y., Suiko, M., Sakakibara, Y., Liu M.-C
    • Journal Title

      Neurosci. Res

      Volume: 64 Pages: 273-279

    • Peer Reviewed
  • [Journal Article] Molecular cloning, expression, and characterization of a novel mouse SULT6 cytosolic sulfotransferase2009

    • Author(s)
      Takahashi, S., Sakakibara, Y., Mishiro, E., Kouriki, H., Nobe, R., Kurogi, K., Yasuda, S., Liu, M.-C., Suiko, M
    • Journal Title

      J. Biochem

      Volume: 146 Pages: 399-405

    • Peer Reviewed
  • [Journal Article] A target-specific approach for the identification of tyrosine-sulfated hemostatic proteins2009

    • Author(s)
      Liu, T. A., Yasuda, S., Williams, F. E., Liu, M.-Y., Suiko, M., Sakakibara, Y., Yang, Y. S., Liu, M.-C
    • Journal Title

      Anal. Biochem

      Volume: 390 Pages: 88-90

    • Peer Reviewed
  • [Journal Article] Snapshot of a Michaelis complex in a sulfuryl transfer reaction : Crystal structure of a mouse sulfotransferase, mSULT1D1, complexed with donor substrate and accepter substrate2009

    • Author(s)
      Teramoto, T., Sakakibara, Y., Liu, M.-C., Suiko, M., Kimura, M., Kakuta, Y
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 383 Pages: 83-87

    • Peer Reviewed
  • [Presentation] 生理活性脂質の硫酸化による機能性発現・制御2012

    • Author(s)
      榊原陽一
    • Organizer
      第2回学際的脂質創生研究部会講演会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2012-01-27
  • [Presentation] マウス硫酸転移酵素(SULT)研究の新展開2010

    • Author(s)
      榊原陽一
    • Organizer
      BMB2010(第33回日本分子生物学会年会、第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸(大会シンポジウム、招待講演)
    • Year and Date
      2010-12-06
  • [Presentation] 食品成分の代謝に関与する硫酸転移酵素の多様な機能2010

    • Author(s)
      榊原陽一
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京(大会シンポジウム、招待講演)
    • Year and Date
      2010-03-30

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Published: 2013-07-31  

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