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2011 Fiscal Year Final Research Report

Mechanism and prevention of stress-induced neurological diseases focused on the action of trace metals

Research Project

  • PDF
Project/Area Number 21580116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied biochemistry
Research InstitutionUniversity of Shizuoka

Principal Investigator

TAMANO Haruna  静岡県立大学, 薬学部, 客員共同研究員 (30322697)

Co-Investigator(Kenkyū-buntansha) TAKEDA Atsushi  静岡県立大学, 薬学部, 教授 (90145714)
Project Period (FY) 2009 – 2011
Keywords微量元素
Research Abstract

Zinc deficiency increased depression-like behavior and suppressed hippocampal neurogenesis. We propose that dietary zinc deficiency is a risk factor for depressive symptoms.
Corticosterone-mediated increase in postsynaptic Zn^<2+> signal in the cytosolic compartment was involved in the attenuation of CA1 LTP after exposure to acute stress. We propose that corticosterone-mediated increase in postsynaptic Zn^<2+> signal, which is induced by acute stress, changes hippocampal function and then is possibly a risk factor under chronic stress circumstances to induce depressive symptoms.

  • Research Products

    (60 results)

All 2012 2011 2010 2009 Other

All Journal Article (19 results) Presentation (41 results)

  • [Journal Article] Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice2012

    • Author(s)
      Atsushi Takeda, Haruka Iwaki, Kazuki Ide, Haruna Tamano and Naoto Oku
    • Journal Title

      Brain Res. Bull

      Volume: 87 Pages: 551-555

  • [Journal Article] Involvement of glucocorticoid-mediated Zn^<2+> signaling in attenuation of hippocampal CA1 LTP by acute stress.2012

    • Author(s)
      Atsushi Takeda, Miki Suzuki, Haruna Tamano, Shunsuke Takada, Kazuki Ide, Naoto Oku
    • Journal Title

      Neurochem. Int

      Volume: 60 Pages: 394-399

  • [Journal Article] Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response2012

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Miki Suzuki, Kazuhiro Sakamoto, Naoto Oku, Hidehiko Yokogoshi
    • Journal Title

      Cell. Mol. Neurobiol

      Volume: 32 Pages: 41-48

  • [Journal Article] Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency2012

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Taisuke Ogawa, Shunsuke Takada, Masaki Ando, Naoto Oku, Mitsugu Watanabe
    • Journal Title

      Behav. Brain Res

      Volume: 226 Pages: 259-264

  • [Journal Article] Transient increase in Zn^<2+> in hippocampal CA1 pyramidal neurons causes reversible memory deficit2011

    • Author(s)
      Atsushi Takeda, Shunsuke Takada, Masatoshi Nakamura, Miki Suzuki, Haruna Tamano, Masaki Ando, and Naoto Oku
    • Journal Title

      PLoS One

      Volume: 6 Pages: 28615

  • [Journal Article] Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory2011

    • Author(s)
      Atsushi Takeda, Kazuhiro Sakamoto, Haruna Tamano, Kotaro Fukura, Naoto Inui, Sang Won Suh, Seok-Joon Won, and Hidehiko Yokogoshi
    • Journal Title

      Cell. Mol. Neurobiol

      Volume: 31 Pages: 1079-1088

  • [Journal Article] Dynamic action of neurometals at the synapse2011

    • Author(s)
      Haruna Tamano and Atsushi Takeda
    • Journal Title

      Metallomics

      Volume: 3 Pages: 656-661

  • [Journal Article] Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol2010

    • Author(s)
      Atsushi Takeda, Shunsuke Takada, Masaki Ando, Kosuke Itagaki, Haruna Tamano, Miki Suzuki, Haruka Iwaki, Naoto Oku
    • Journal Title

      Neuroscience

      Volume: 171 Pages: 443-450

  • [Journal Article] Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice2010

    • Author(s)
      Haruna Tamano, Fumika Kan, Naoto Oku, Atsushi Takeda
    • Journal Title

      Brain Res. Bull

      Volume: 83 Pages: 351-55

  • [Journal Article] Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components2010

    • Author(s)
      Atsushi Takeda, Miki Suzuki, Haruna Tamano, Masaki Ando, Naoto Oku
    • Journal Title

      Brain Res

      Volume: 1354 Pages: 188-195

  • [Journal Article] Increases in extracellular zinc in the amygdala in acquisition and recall of fear experience and their roles in response to fear2010

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Sachie Imano, Naoto Oku
    • Journal Title

      Neuroscience

      Volume: 168 Pages: 715-722

  • [Journal Article] Susceptibility to stress in young rats after 2-week zinc deprivation2010

    • Author(s)
      Mitsugu Watanabe, Haruna Tamano, Toshinori Kikuchi, Atsushi Takeda
    • Journal Title

      Neurochem. Int

      Volume: 56 Pages: 410-416

  • [Journal Article] Insight into neurozinc in the hippocampus2010

    • Author(s)
      Atsushi Takeda and Haruna Tamano
    • Journal Title

      Biomed. Res. Trace Elements

      Volume: 21 Pages: 194-203

  • [Journal Article] Zinc signaling through glucocorticoid and glutamate signaling in stressful circumstances2010

    • Author(s)
      Atsushi Takeda and Haruna Tamano
    • Journal Title

      J. Neurosci. Res

      Volume: 88 Pages: 3002-3010

  • [Journal Article] Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats2009

    • Author(s)
      Sang Won Suh, Seok Joon Won, Aaron M. Hamby, Yang Fan, Christian T. Sheline, Haruna Tamano, Atsushi Takeda and Jialing Liu
    • Journal Title

      J. Cereb. Blood Flow Metab

      Volume: 29 Pages: 1579-1588

  • [Journal Article] Behavior in the forced swim testand neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation2009

    • Author(s)
      Haruna Tamano, Fumika Kan, Mika Kawamura, Naoto Oku and Atsushi Takeda
    • Journal Title

      Neurochem. Int

      Volume: 55 Pages: 536-541

  • [Journal Article] High K+-induced increase in extracellular glutamate in zinc deficiency and endogenous zinc action2009

    • Author(s)
      Atsushi Takeda, Hiromasa Itoh, Haruna Tamano and Naoto Oku
    • Journal Title

      J. Health Sci

      Volume: 55 Pages: 405-412

  • [Journal Article] Insight into zinc signaling from dietary zinc deficiency2009

    • Author(s)
      Atsushi Takeda and Haruna Tamano
    • Journal Title

      Brain Res. Rev

      Volume: 62 Pages: 33-44

  • [Journal Article] Proposed glucocorticoid-mediated zinc signaling in the hippocampus

    • Author(s)
      Atsushi Takeda and Haruna Tamano
    • Journal Title

      Metallomics

      Volume: (in press)

  • [Presentation] ストレスによる海馬長期増強の減弱に対する緑茶テアニン摂取の効果とそのメカニズム2012

    • Author(s)
      玉野春南、武田厚司、鈴木美希、坂本和洋、奥直人、横越英彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
  • [Presentation] 海馬歯状回におけるシナプス亜鉛の動態と長期増強における役割2012

    • Author(s)
      小川泰右、武田厚司、玉野春南、高田俊介、安藤正樹、奥直人
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
  • [Presentation] Significance of Serum Glucocorticoid and Chelatable Zinc in Depression and Cognition in Zinc Deficiency2012

    • Author(s)
      Haruna Tamano, Atsushi Takeda, Taisuke Ogawa, Shunsuke Takada, Masaki Ando, Naoto Oku
    • Organizer
      International Society for Zinc Biology 2012 Meeting
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2012-01-17
  • [Presentation] 亜鉛不足による隔離飼育マウスの攻撃性増大のメカニズムと抑肝散の効果2011

    • Author(s)
      井出和希, 岩城はるか, 玉野春南, 武田厚司, 奥直人, 横越英彦
    • Organizer
      フォーラム2011:衛生薬学・環境トキシコロジー
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-27
  • [Presentation] 緑茶成分テアニン摂取によるラット海馬神経新生の促進と認知記憶の向上2011

    • Author(s)
      玉野春南, 武田厚司, 坂本和洋, 福羅光太郎, Suh Sang Won, 奥直人, 横越英彦
    • Organizer
      フォーラム2011:衛生薬学・環境トキシコロジー
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-27
  • [Presentation] Effect of theanine on hippocampal neurogenesis and cognitive function in young rats2011

    • Author(s)
      Hidehiko Yokogoshi, Atsushi Takeda, Haruna Tamano, Inui Naoto, Sang Won Suh, Seok-Joon Won, Kazuhiro Sakamoto
    • Organizer
      The 4th International Conference on Health and Longevity Science
    • Place of Presentation
      Shizuoka
    • Year and Date
      2011-10-21
  • [Presentation] Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response2011

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Miki Suzuki, Sang Won Suh, Kazuhiro Sakamoto, Kotaro Fukura, Hidehiko Yokogoshi, Naoto Oku
    • Organizer
      The 4th International Conference on Halth and Longevity Science
    • Place of Presentation
      Shizuoka
    • Year and Date
      2011-10-21
  • [Presentation] Enhancement of seizure susceptibility of Noda epileptic rat(NER) by zinc chelators2011

    • Author(s)
      Masashi Iida, Atsushi Takeda, Masaki Ando, Masatoshi Nakamura, Haruna Tamano, Naoto Oku
    • Organizer
      IX International Society for trace element research in humans
    • Place of Presentation
      Belek, Turkey
    • Year and Date
      2011-10-17
  • [Presentation] Depression-like behavior and object recognition memory in zinc deficiency ; involvement of glucocorticoid2011

    • Author(s)
      Haruna Tamano, Taisuke Ogawa, Shunsuke Takada, Masaki Ando, Naoto Oku, and Atsushi Takeda
    • Organizer
      IX International Society for trace element research in humans
    • Place of Presentation
      Belek, Turkey
    • Year and Date
      2011-10-17
  • [Presentation] Depression-like behavior and object recognition memory in zinc deficiency ; involvement of glucocorticoid2011

    • Author(s)
      Haruna Tamano, Taisuke Ogawa, Shunsuke Takada, Masaki Ando, Naoto Oku, Tomomi Hagiwara, Mitsugu Watanabe, Atsushi Takeda
    • Organizer
      The 34th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-09-17
  • [Presentation] Impairment of memory processing by dyshomeostasis of chelatable zinc in the hippocampus2011

    • Author(s)
      Haruna Tamano, Taisuke Ogawa, Shunsuke Takada, Masaki Ando, Atsushi Takeda, Naoto Oku
    • Organizer
      5th International Conference on Metals and Genetics
    • Place of Presentation
      Kobe
    • Year and Date
      2011-09-06
  • [Presentation] 亜鉛欠乏食ラットのうつ様行動と物体認識記憶.グルココルチコイドの関与.2011

    • Author(s)
      小川泰右、玉野春南、高田俊介、安藤正樹、武田厚司、奥直人
    • Organizer
      第22回日本微量元素学会
    • Place of Presentation
      京都
    • Year and Date
      2011-07-02
  • [Presentation] 亜鉛欠乏食飼育ラットのうつ様行動増かのメカニズム解析2011

    • Author(s)
      小川泰右、玉野春南、高田俊介、安藤正樹、武田厚司、奥直人
    • Organizer
      第75回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2011-05-28
  • [Presentation] 亜鉛欠乏食飼育ラットの老化モデルとしての可能性~海馬歯状回長期増強と学習行動との関係~2011

    • Author(s)
      小川泰右、武田厚司、玉野春南、鈴木美希、渡辺貢、萩原智美、奥直人
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
  • [Presentation] 亜鉛欠乏食飼育マウスの攻撃行動と抑肝散の効果2011

    • Author(s)
      岩城はるか, 玉野春南, 武田厚司, 奥直人
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
  • [Presentation] 緑茶テアニン摂取による若齢ラットの海馬神経新生の促進と学習行動の向上2011

    • Author(s)
      玉野春南、武田厚司、坂本和洋、乾直人、Sang Won Suh、横越英彦
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
  • [Presentation] ストレス負荷による海馬CA1 LTP抑制における亜鉛の関与2011

    • Author(s)
      鈴木美希, 玉野春南, 安藤正樹, 武田厚司, 奥直人
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
  • [Presentation] Reduction in hippocampal neurogenesis and increase in depression-like behavior in zinc-deficient young rats2010

    • Author(s)
      Haruna Tamano, Sang Won Suh, and Atsushi Takeda
    • Organizer
      Society for Neuroscience 40th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-17
  • [Presentation] Differential effects of Zinc Influx via AMPA/kainate Receptor Activation on Subsequent Induction of Hippocampal CA1 LTP Components2010

    • Author(s)
      Miki Suzuki, Haruna Tamano, Masaki Ando, Atsushi Takeda, Naoto Oku
    • Organizer
      Society forNeuroscience 40th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-17
  • [Presentation] Ameliorative Effect of Yokukansan on Social Isolation-induced Aggressive Behavior of Zinc-deficient Young Mice2010

    • Author(s)
      Haruka Iwaki, Atsushi Takeda, Haruna Tamano, Fumika Kan, Naoto Oku
    • Organizer
      Society for Neuroscience 40th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-16
  • [Presentation] Increases in Extracellular Zinc in the Amygdala in Acquisition and Recall of Fear Experience and their Roles in Response to Fear2010

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Sachie Imano, Naoto Oku
    • Organizer
      Society for Neuroscience 40th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-16
  • [Presentation] Facilitation in hippocampal neurogenesis in young rats fed theanine, an amino acid in tea leaves, and its effect on cognitive function2010

    • Author(s)
      Kazuhiro Sakamoto, Atsushi Takeda, Haruna Tamano, Inui Naoto, Sang Won Suh, Seok-Joon Won, Hidehiko Yokogoshi
    • Organizer
      Society for Neuroscience 40th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-15
  • [Presentation] Impairment of Cognitive Function and Hippocampal Long-term Potentiation after Acute Exposure to Clioquinol2010

    • Author(s)
      Shunsuke Takada, Atsushi Takeda, Masaki Ando, Kosuke Itagaki, Haruna Tamano, Miki Suzuki, Haruka Iwaki, Naoto Oku
    • Organizer
      Society for Neuroscience 40th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
  • [Presentation] AMPA受容体活性化を介した亜鉛流入による海馬CA1 LTPの増強と減弱2010

    • Author(s)
      鈴木美希, 玉野春南, 安藤正樹, 武田厚司, 奥直人
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-02
  • [Presentation] Reduction in hippocampal neurogenesis and increase in depression-like behavior in zinc-deficient young rats2010

    • Author(s)
      Haruna Tamano, Sang Won Suh, Atsushi Takeda
    • Organizer
      The 60th Fujihara Seminar
    • Place of Presentation
      Osaka
    • Year and Date
      2010-10-30
  • [Presentation] Effect of theanine on young rat's hippocampal neurogenesis and cognitive function2010

    • Author(s)
      Kazuhiro Sakamoto, Atsushi Takeda, Haruna Tamano, Naoto Inui, Sang Won Suh, Seok Joon Won, Hidehiko Yokogoshi
    • Organizer
      ICOS 2010 The 4thInternational Conference on O-CHA(Tea) Culture and Science
    • Place of Presentation
      Shizuoka
    • Year and Date
      2010-10-26
  • [Presentation] Reduction in hippocampal neurogenesis and increase in depression-like behavior in zinc-deficient young rats2010

    • Author(s)
      Atsushi Takeda, Haruna Tamano, Inui Naoto, Sang Won Suh, Naoto Oku
    • Organizer
      The 3rd International Conference on Halth and Longevity Science
    • Place of Presentation
      Shizuoka
    • Year and Date
      2010-10-16
  • [Presentation] Facilitation in hippocampal neurogenesis in young rats fed theanine, an amino acid in tea leaves, and its effect on cognitive function2010

    • Author(s)
      Kazuhiro Sakamoto, Atsushi Takeda, Haruna Tamano, Inui Naoto, Sang Won Suh, Seok-Joon Won, Hidehiko Yokogoshi
    • Organizer
      The 3rd International Conference on Health and Longevity Science
    • Place of Presentation
      Shizuoka
    • Year and Date
      2010-10-16
  • [Presentation] Reduction in hippocampal neurogenesis and increase in depression-like behavior in zinc-deficient young rats2010

    • Author(s)
      Haruna Tamano, Sang Won Suh, Mitsugu Watanabe, Toshinori Kikuchi, Atsushi Takeda
    • Organizer
      Neuro 2010
    • Place of Presentation
      Kobe
    • Year and Date
      2010-09-04
  • [Presentation] Differential effects of Zinc Influx via AMPA/kainate Receptor Activation on Subsequent Induction of Hippocampal CA1 LTP Components2010

    • Author(s)
      Miki Suzuki, Haruna Tamano, Masaki Ando, Atsushi Takeda and Naoto Oku
    • Organizer
      Neuro 2010
    • Place of Presentation
      Kobe
    • Year and Date
      2010-09-04
  • [Presentation] 亜鉛摂取不足ラットにおける海馬ニューロン新生の減少と学習障害との関係2010

    • Author(s)
      玉野春南, 武田厚司、Sang Won Suh, 奥直人
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
  • [Presentation] 幼若ラットの海馬CA1 LTPと亜鉛の抑制作用2010

    • Author(s)
      板垣宏亮, 玉野春南, 武田厚司, 奥直人
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
  • [Presentation] 亜鉛によるNMDA受容体に依存した海馬CA1 LTPの促進と抑制2010

    • Author(s)
      鈴木美希, 玉野春南, 安藤正樹, 武田厚司, 奥直人
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
  • [Presentation] 緑茶成分テアニンによるラットの記憶力向上作用2010

    • Author(s)
      坂本和洋, 乾直人, 源川博久, 玉野春南, 武田厚司, 横越英彦
    • Organizer
      第25回茶学術研究会講演会
    • Place of Presentation
      静岡
    • Year and Date
      2010-03-11
  • [Presentation] 亜鉛不足時のうつ様行動と海馬グルタミン酸作動性神経の興奮性との関係2009

    • Author(s)
      玉野春南, 武田厚司, 伊東宏昌, 河村美香、奥直人
    • Organizer
      フォーラム2009:衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-05
  • [Presentation] 亜鉛による海馬CA1 LTPの促進と抑制2009

    • Author(s)
      鈴木美希, 玉野春南, 安藤正樹, 武田厚司, 奥直人
    • Organizer
      フォーラム2009:衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-05
  • [Presentation] 亜鉛摂取不足時のうつ様行動と学習行動2009

    • Author(s)
      玉野春南, 武田厚司, 伊東宏昌, 河村美香, 奥直人
    • Organizer
      メタロチオネインおよびメタルバイオサイエンス研究会2009
    • Place of Presentation
      東京
    • Year and Date
      2009-10-16
  • [Presentation] Protective effect of theanine on attenuation of long-term potentiation at hippocampal CA1 synapses after acute behavioral stress2009

    • Author(s)
      Miki Suzuki, Atsushi Takeda, Haruna Tamano, Naoto Oku, Kazuhiro Sakamoto, Naoto Inui and Hidehiko Yokogoshi
    • Organizer
      The 2nd International Conference on Health and Longevity Sciences
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2009-10-01
  • [Presentation] 低亜鉛食ラットにおけるうつ様行動の増加とその回復2009

    • Author(s)
      渡辺貢, 玉野春南, 菊池利典, 青山美子, 武田厚司, 奥直人
    • Organizer
      第20回日本微量元素学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-03
  • [Presentation] ストレス負荷による海馬シナプス可塑性の抑制2009

    • Author(s)
      鈴木美希, 安藤正樹, 玉野春南, 武田厚司, 奥直人
    • Organizer
      第20回日本微量元素学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-02
  • [Presentation] 海馬長期増強における亜鉛の作用とストレスとの関係2009

    • Author(s)
      武田厚司, 安藤正樹, 鈴木美希, 玉野春南, 奥直人
    • Organizer
      第19回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-06-11

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Published: 2013-07-31  

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