2011 Fiscal Year Final Research Report
Mechanism and prevention of stress-induced neurological diseases focused on the action of trace metals
| Project/Area Number |
21580116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | University of Shizuoka |
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Principal Investigator |
TAMANO Haruna 静岡県立大学, 薬学部, 客員共同研究員 (30322697)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Atsushi 静岡県立大学, 薬学部, 教授 (90145714)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 微量元素 |
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| Research Abstract |
Zinc deficiency increased depression-like behavior and suppressed hippocampal neurogenesis. We propose that dietary zinc deficiency is a risk factor for depressive symptoms.
Corticosterone-mediated increase in postsynaptic Zn^<2+> signal in the cytosolic compartment was involved in the attenuation of CA1 LTP after exposure to acute stress. We propose that corticosterone-mediated increase in postsynaptic Zn^<2+> signal, which is induced by acute stress, changes hippocampal function and then is possibly a risk factor under chronic stress circumstances to induce depressive symptoms.
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