2011 Fiscal Year Final Research Report
Discovery of cell division regulating factors using cancer chemopreventive microbial metabolites
| Project/Area Number |
21580132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Kinki University |
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Principal Investigator |
IIDA Akira 近畿大学, 農学部, 教授 (40202816)
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| Co-Investigator(Kenkyū-buntansha) |
KANEKO Masafumi 高崎健康福祉大学, 薬学部, 准教授 (50433636)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 菌類 / シグナル伝達 / タンパク質 / がん / 抗発がんプロモーター / 発がんプロモーター / トリコテカン / Trichothecium roseum |
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| Research Abstract |
Sufficient quantities of sesquiterpene TTC-A, which is a metabolite of Trichothecium roseum showing anti-tumor promoting and tumor promoting effects simultaneously, were obtained by selecting various strains and modifying cultural conditions. TTC-A is known to be an inducer of multinucleated Raji cells. This was deduced to result from modulation of cell cycles regulated by signal transductions associated with ras gene and cell differentiation.
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