RESEARCH FOR THE MECHANISM OF MUCIN SECRETORY EFFECTS BY DIETARY FIBER AND ITS PHYSIOLOGICAL SIGNIFICANCE

2011 Fiscal Year Final Research Report

• Project/Area Number: 21580136
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Shizuoka University
• Principal Investigator: MORITA Tatsuya 静岡大学, 農学部, 教授 (90332692)
• Project Period (FY): 2009 – 2011
• Keywords: 栄養化学 / 食物繊維 / ムチン

Research Abstract

Mucin is a key component of the gut barrier that prevents potential pathogens and antigens from gaining access to the underlying epithelium. The study examined physicochemical properties of dietary fiber(DF) that determine small intestinal mucin secretion. It turned out that small intestinal mucins were secreted in proportion to the settling volume in water(bulk-forming properties) of water-insoluble DF or the viscosity of water-soluble DF. The stimulatory effects of both soluble and insoluble DF on mucin secretion appear to be linked to the subsequent increase in goblet cell number.

Research Products

• [Journal Article] Degree of polymerization of inulin-type fructans differentially affects number of lactic acid bacteria, intestinal immune functions, and immunoglobulin A secretion in the rat cecum (2011)
  • Author(s): Ito, H., Takemura, N., Sonoyama, K., Kawagishi, H., Topping, D.L., Conlon, M.A., Morita, T
  • Journal Title: J Agric Food Chem Volume: 59 Pages: 5771-5778
  • Peer Reviewed
• [Journal Article] Comparison of gut microbiota and allergic reactions in BALB/c mice fed different cultivars of rice (2010)
  • Author(s): Sonoyama, K., Ogasawara, T., Goto, H., Yoshida, T., Takemura, N., Fujiwara, R., Watanabe, J., Ito, H., Morita, T, Tokunaga, Y., Yanagihara, T.
  • Journal Title: Brit J Nutr Volume: 103 Pages: 218-226
  • Peer Reviewed
• [Journal Article] トリニトロヘンセンスルホン酸を用いた再発大腸炎モテルの免疫学的解析 (2010)
  • Author(s): 伊藤弘幸、加藤俊彦、河田伊織、尾藤寛之、河岸洋和、桐山修八、森田達也
  • Journal Title: 日本食物繊維学会誌 Volume: 14 Pages: 33-44
  • Peer Reviewed
• [Journal Article] Inulin prolongs survival of intragastrically administered Lactobacillus plantarum No. 14 in the gut of mice fed a high-fat diet (2010)
  • Author(s): Takemura, N., Hagio, M., Ishizuka, S., Ito, H., Morita, T, Sonoyama, K.
  • Journal Title: J Nutr Volume: 141 Pages: 1963-1969
  • Peer Reviewed
• [Journal Article] Effects of fructo-oligosaccharide on DSS-induced colitis differ in mice fed non-purified and purified diets (2010)
  • Author(s): Goto, H., Takemura, N., Ogasawara, T., Sasajima, N., Watanabe, J., Ito, H., Morita, T, Sonoyama, K.
  • Journal Title: J Nutr Volume: 140 Pages: 2121-2127
  • Peer Reviewed
• [Journal Article] Short-chain inulin-like fructansreduce endotoxin and bacterial translocations and attenuate the development of TNBS-induced colitis in rats (2009)
  • Author(s): Ito, H., Tanabe, H., Kawagishi, H., Wada, T., Sugiyama, K., Kiriyama, S., Morita, T
  • Journal Title: Dig Dis Sci Volume: 54 Pages: 2100-2108
  • Peer Reviewed
• [Journal Article] Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats (2009)
  • Author(s): Ito, H., Eiko, A., Sugiyama, K., Sonoyama, K., Kiriyam, S., Morita, T
  • Journal Title: J Nutr Volume: 139 Pages: 1640-1647
  • Peer Reviewed
• [Journal Article] Response of Gut Microbiota to Fasting and Hibernation in Syrian Hamsters (2009)
  • Author(s): Sonoyama, K., Fujiwara, R., Takemura, N., Ogasawaram T., Watanabe, J., Ito, H., Morita, T
  • Journal Title: J Applied and Environmental Microbiology Volume: 75(20) Pages: 6451-6456
  • Peer Reviewed
• [Journal Article] ルミナコイトの嵩形成能および発酵性かラット小腸および盲腸でのムチン分泌に及ほす影響 (2009)
  • Author(s): 伊藤弘幸、加藤俊彦、河田伊織、森田達也、桐山修八
  • Journal Title: 日本食物繊維学会誌 Volume: 13 Pages: 107-117
  • Peer Reviewed
• [Journal Article] Ameliorating effects of short-chain inulin-like fructans on the healing stage of trinitrobenzene sulfonic acid-induced colitis in rats
  • Author(s): Hino, S., Ito, H., Bito, H., Kawagishi, H., Morita, T.
  • Journal Title: Biosci Biotechnol Biochem Volume: (in press)
  • Peer Reviewed