2011 Fiscal Year Final Research Report
Elucidation of the role of MT-SP1 in the intestinal epithelial turnover and exploration of food components that control the activation of the molecule.
| Project/Area Number |
21580138
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
TSUZUKI Satoshi 京都大学, 大学院・農学研究科, 助教 (50283651)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Kazuo 京都大学, 大学院・農学研究科, 准教授 (80213148)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUYE Kuniyo 京都大学, 大学院・農学研究科, 教授 (10223249)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腸上皮 / 代謝回転 / 基底膜 / MT-SP1 / 活性化制御 |
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| Research Abstract |
We found that a membrane-bound serine protease MT-SP1 induces detachment and apoptosis of intestinal epithelial IEC-6 cells. Also, we found that a recombinant form of MT-SP1 pseudozymogen exhibits a protease activity and that the activity is not seen in the presence of NaCl.
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