Cardioprotective effects of nicotinic acid via Sirt1 activation

2011 Fiscal Year Final Research Report

• Project/Area Number: 21580139
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Shimane University
• Principal Investigator: HARA Nobumasa 島根大学, 医学部, 講師 (20284028)
• Project Period (FY): 2009 – 2011
• Keywords: ニコチン酸 / NAD / Sirt1 / 心筋細胞 / ストレス / 細胞死 / 高脂血症薬

Research Abstract

Nicotinic acid(NA) exhibits various pharmacological actions including cardioprotection against oxidative stress. However, mechanisms underlying the reported actions of NA remain unclear. We have found that NA increases cellular NAD contents in primary rat cardiomyocytes and that the vitamin protects the cardiomyocytes against oxidative stress-induced damage by increasing cellular NAD contents.

Research Products

• [Journal Article] Nicotinamide phospho-ribosyltransferase/Visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma (2011)
  • Author(s): Hara N, Yamada K, Shibata T, Osago H, Tsuchiya M
  • Journal Title: PLoS ONE Volume: Vol 6, No.8 Pages: e22781
  • DOI: doi:101371/journal.pone.0022781
  • Peer Reviewed
• [Journal Article] Interferon-γelevates nicotinamide N-methyltransferase activity and nicotinamide level in human glioma cells (2010)
  • Author(s): Yamada K, Miyazaki T, Hara N, Tsuchiya M
  • Journal Title: J. Nutr. Sci. Vitaminol Volume: Vol 56, No.2 Pages: 83-86
  • URL: http://dx.doi.org/10.3177/jnsv.56.83
  • Peer Reviewed
• [Presentation] ニコチン酸の薬理作用は細胞内NADレベルの増加を介するか? (2011)
  • Author(s): 原伸正, 山田和夫, 柴田朋子, 長子晴美, 土屋美加子
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 20110921-24
• [Presentation] LC/MS/MSを用いた細胞の酸処理による酸化および還元型NADPの同時定量法の確立 (2011)
  • Author(s): 山田和夫, 原伸正, 長子晴美, 土屋美加子
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 20110921-24
• [Presentation] Visfatin/nicotinamide phosphoribosyltransferase does not function as an extracellular NAD synthetic enzyme (2010)
  • Author(s): Hara N, Yamada K, Osago H, Shibata T, Tsuchiya M
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: 神戸国際展示場(神戸市)
  • Year and Date: 20101207-10
• [Presentation] 質量分析によるNADH酸分解産物を用いたNADH定量法とこの方法の細胞の酸化還元状態の解析への応用の検討 (2010)
  • Author(s): 山田和夫, 原伸正, 長子晴美, 柴田朋子, 土屋美加子
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: 神戸国際展示場(神戸市)
  • Year and Date: 20101207-10
• [Presentation] Quantitative determination of NAD turnover using deuterium-labeled nicotinamide and nicotinic acid (2009)
  • Author(s): 原伸正, 山田和夫, 柴田朋子, 長子晴美, 土屋美加子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 20091021-24
• [Presentation] (招待講演) Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human cells (2009)
  • Author(s): Hara N, Yamada K, Shibata K, Osago H, Tsuchiya M
  • Organizer: NAD METABOLISM AND SIGNALING
  • Place of Presentation: CAREFREE, ARIZONA, USA
  • Year and Date: 20090621-26