Exploring of food components with neurotrophic activity

2011 Fiscal Year Final Research Report

• Project/Area Number: 21580140
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Okayama University
• Principal Investigator: ITO Hideyuki 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70253002)
• Project Period (FY): 2009 – 2011
• Keywords: ポリフェノール / カテキン / キサントン / 海馬 / 神経突起伸展作用 / アルツハイマー型認知症 / 脳内移行

Research Abstract

We have previously reported that chlorogenic acid, catechin and epicatechin were found to promote neuronal differentiation by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. In this project, we evaluated brain absorption of these active compounds after oral administration to rat. Catechin was not detected in brain after catechin ingestion to rat, whereas its metabolite 3'-O-methylcatechin was observed by HPLC-ESI-MS/MS method. Our findings raise the possibility that studying the bioavailability of natural products is important to clarify the bioactive principles of their biological activities.

Research Products

• [Journal Article] Antioxidative properties of functional polyphenols and their metabolites assessed by an ORAC assay (2012)
  • Author(s): Ishimoto, H., Tai, A., Yoshimura, M., Amakura, Y., Yoshida, T., Hatano, T., and Ito, H.
  • Journal Title: Biosci. Biotech. Biochem. Volume: 76 Pages: 395-399
  • Peer Reviewed
• [Journal Article] UV and MS identification of urolithins and nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals (2011)
  • Author(s): Gonzalez-Barrio, R., Truchado, P., Ito, H., Espin, J. C., Tomas-Barberan, F. A.
  • Journal Title: J. Agric. Food. Chem. Volume: 59 Pages: 1152-1162
  • Peer Reviewed
• [Journal Article] Effects of Mace and Nutmeg on Human Cytochrome P450 3A4 and 2C9 Activity (2010)
  • Author(s): Kimura, Y., Ito, H., Hatano, T.
  • Journal Title: Biol. Pharm. Bull. Volume: 33 Pages: 1977-1982
  • Peer Reviewed
• [Journal Article] Inhibitory effects of polyphenols on human cytochrome P450 3A4and 2C9 activity (2010)
  • Author(s): Kimura, Y., Ito, H., Ohnishi, R., and Hatano, T.
  • Journal Title: Food Chem. Toxicol. Volume: 48 Pages: 429-435
  • Peer Reviewed
• [Presentation] Metabolites of Ellagitannins and Their Antioxidant Activity (2010)
  • Author(s): Hideyuki Ito
  • Organizer: 7th Tannin Conference
  • Place of Presentation: Berlin, Germany
  • Year and Date: 20100829-0902
• [Presentation] Neurotrophic Activity of Polyphenols and Related Compounds using Primary Culturesof Fetal Rat Hippocampal Neurons (2010)
  • Author(s): Hideyuki Ito, Xiu-Lan Sun, Makiko Watanabe, Motoi Okamoto and Tsutomu Hatano
  • Organizer: 25th International Conference on Polyphenols
  • Place of Presentation: Montpellier, France
  • Year and Date: 20100824-27
• [Presentation] 遠志成分の海馬初代培養細胞における神経突起伸展作用 (2010)
  • Author(s): 伊東秀之, 孫秀蘭, 渡辺真紀子, 岡本基, 波多野力
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 20100328-30
• [Presentation] ポリフェノールの生体内代謝物とその生理機能 (2009)
  • Author(s): 伊東秀之
  • Organizer: 第121回日本薬学会中国四国支部例会
  • Place of Presentation: 岡山
  • Year and Date: 2009-06-20
• [Book] Chemistry and biology of ellagitannins, Ellagitannins renewed the concept of tannins, An underestimated class of bioactive plant polyphenols- (2009)
  • Author(s): Okuda, T., Yoshida, T., Hatano, T., and Ito, H., Quideau, S.
  • Total Pages: 1-54
  • Publisher: World Scientific, Singapore
• [Book] Chemistry and biology of ellagitannins, Structural diversity and antimicrobial activities of ellagitannins, An underestimated class of bioactive plant polyphenols- (2009)
  • Author(s): Yoshida, T., Hatano, T., Ito, H., and Okuda, T., Quideau, S.
  • Total Pages: 55-93
  • Publisher: World Scientific, Singapore