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2011 Fiscal Year Final Research Report

Studies on the structure-activity relationship of flaxseed lignan, multifunctional physiologically active substance

Research Project

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Project/Area Number 21580142
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionEhime University

Principal Investigator

SUGAHARA Takuya  愛媛大学, 農学部, 准教授 (00263963)

Co-Investigator(Kenkyū-buntansha) YAMAUCHI Satoshi  愛媛大学, 農学部, 教授 (00243808)
Project Period (FY) 2009 – 2011
Keywordsアマニ / セコイソラリシレジノール / マタイレジノール / リグナン / 抗アレルギー / 免疫促進 / 脂肪蓄積抑制 / 構造活性相関
Research Abstract

One of flaxseed lignans, matairesinol(Mat), especially(-)-Mat suppressed IgE production, and allergy-suppressing effects in allergy model mice. In addition,(-)-secoisolariciresinol(SECO) strongly suppressed lipid accumulation in adipose cells, even though(-)-SECO strongly induced adipogenesis in pre-adipocyte cells.(-)-SECO enhanced adiponectin production in adipocytes. Moreover,(-)-SECO obviously suppressed fatty liver in diabetic model mice.

  • Research Products

    (20 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (11 results) Book (1 results) Remarks (1 results)

  • [Journal Article] (-)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 mice.2012

    • Author(s)
      S. Tominaga, K. Nishi, S. Nishimoto, Y. Nakashima, K. Akiyama, S. Yamauchi and T. Sugahara
    • Journal Title

      Food Funct.

      Volume: 3 Pages: 76-82

    • Peer Reviewed
  • [Journal Article] Immunomodulatory effect of(-)-matairesinol in vivo and ex vivo.2011

    • Author(s)
      M. Yamawaki, K. Nishi, S. Nishimoto, S. Yamauchi, K. Akiyama, T. Kishida, M. Maruyama, H. Nishiwaki and T. Sugahara
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 75 Pages: 859-863

    • Peer Reviewed
  • [Journal Article] Antifungal activity of morinol B derivatives of tetrahydropyran sesquilignan.2010

    • Author(s)
      K. Masuda, H. Nishiwaki, K. Akiyama, S. Yamauchi, M. Maruyama, T. Sugahara and T. Kishida
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 74 Pages: 2071-2076

    • Peer Reviewed
  • [Journal Article] IgE suppressive activity of(-)-matairesinol and structure-activity relationship.2010

    • Author(s)
      S. Kawahara, I. Iwata, E. Fujita, M. Yamawaki, H. Nishiwaki, T. Sugahara, S. Yamauchi, K. Akiyama and T. Kishida
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 74 Pages: 1878-1883

    • Peer Reviewed
  • [Journal Article] Improved syntheses of morinol C and D by employing Mizoroki-Heck 4 reaction and their cytotoxic and antimicrobial activities.2010

    • Author(s)
      K. Ogura, T. Sugahara, M. Maruyama, K. Akiyama and S. Yamauchi
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 74 Pages: 1641-1644

    • Peer Reviewed
  • [Journal Article] Antimicrobial activity of stereoisomers of butane type of lignans.2009

    • Author(s)
      Y. Kawaguchi, S. Yamauchi, K. Masuda, H. Nishiwaki, K. Akiyama, M. Maruyama, T. Sugahara, T. Kishida and Y. Koba
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 73 Pages: 1806-1810

    • Peer Reviewed
  • [Journal Article] Syntheses and antimicrobial activity of tetrasubstituted tetrahydrofuran lignan stereoisomers.2009

    • Author(s)
      T. Nakato, S. Yamauchi, R. Tago, K. Akiyama, M. Maruyama, T. Sugahara, T. Kishida and Y. Koba
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 73 Pages: 1608-1617

    • Peer Reviewed
  • [Presentation] Effect of flaxseed lignan on lipid accumulation in adipocytes.2011

    • Author(s)
      T. Sugahara, S. Tominaga, S. Yamauchi, S. Nishimoto and K. Nishi
    • Organizer
      International Conference on Food Factors(ICoFF) 2011
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      20111120-23
  • [Presentation] ブタノール型セコシクロリグナンの合成と培養細胞に対する活性2011

    • Author(s)
      富山千聖, 西脇寿, 西甲介, 菅原卓也, 山内聡
    • Organizer
      2011年度日本農芸化学会西日本支部・中四国支部合同大会(要旨集)
    • Place of Presentation
      宮崎
    • Year and Date
      20110916-17
  • [Presentation] Anti-cancer effect of lectin from red sea alga.2011

    • Author(s)
      T. Sugahara
    • Organizer
      The 2nd International Symposium on Temulawak
    • Place of Presentation
      Bogor Indonesia
    • Year and Date
      20110525-27
  • [Presentation] 細胞毒性報告のあるセコシクロリグナンの全立体異性体の合成と細胞に対する活性2011

    • Author(s)
      富山千聖, 西脇寿, 山脇愛実, 菅原卓也, 山内聡
    • Organizer
      日本農芸化学会2011年度大会(要旨集)
    • Place of Presentation
      京都
    • Year and Date
      20110325-28
  • [Presentation] Effect of secoisolariciresinol on adipogenesis.2010

    • Author(s)
      T. Sugahara, S. Tominaga, S. Yamauchi, M. Maruyama, K. Akiyama and S. Nishimoto
    • Organizer
      The 14th International Biotechnology Symposium and Exhibition(IBS2010)
    • Place of Presentation
      Rimini, Italy
    • Year and Date
      20100914-18
  • [Presentation] (-)マタイレジノールの構造と細胞毒性活性、IgE抗体産生抑制活性との関係2010

    • Author(s)
      河原沙耶, 岩田一平, 山内聡, 菅原卓也, 藤田絵里子, 山脇愛美, 岸田太郎, 秋山浩一
    • Organizer
      日本農芸化学会2010年度大会(要旨集)
    • Place of Presentation
      東京
    • Year and Date
      20100327-30
  • [Presentation] Secoisolariciresinolの高脂肪食餌性肥満に与える影響2010

    • Author(s)
      冨永詩央里, 西本壮吾, 山内聡, 丸山雅史, 秋山浩一, 菅原卓也
    • Organizer
      日本農芸化学会2010年度大会(要旨集)
    • Place of Presentation
      東京
    • Year and Date
      20100327-30
  • [Presentation] (-)-morinol Bの7位のベンゼン環上の置換基が抗かび活性に与える影響2010

    • Author(s)
      升田健太, 山内聡, 西脇寿, 秋山浩一, 菅原卓也
    • Organizer
      日本農芸化学会2010年度大会(要旨集)
    • Place of Presentation
      東京
    • Year and Date
      20100327-30
  • [Presentation] Evaluation of food functions by animal cell culture and experimental animals.2010

    • Author(s)
      T. Sugahara, K. Nishi and S. Nishimoto
    • Organizer
      Gadjah Mada-Ehime Network(GEN) 2010
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2010-08-07
  • [Presentation] (-)-Matairesinolの免疫調節活性に関する研究2009

    • Author(s)
      山脇愛実, 菅原卓也, 山内聡, 西本壮吾, 岸田太郎, 秋山浩一, 丸山雅史, 西脇寿
    • Organizer
      日本農芸化学会関西・中四国・西日本支部、日本栄養・食糧学会九州・沖縄支部、および日本食品科学工学会西日本支部2009年度合同沖縄大会(要旨集)
    • Place of Presentation
      沖縄
    • Year and Date
      20091030-31
  • [Presentation] Studies on the immunoregulatory functions of orange.2009

    • Author(s)
      T. Sugahara
    • Organizer
      Seminar National 2009 Developing local-resource-based technology
    • Place of Presentation
      Yogyakarta, Indonesia
    • Year and Date
      2009-12-02
  • [Book] The effect of secoisolariciresinol on 3T3-L1 adipocytes and the relationship between molecular structure and the activity.2010

    • Author(s)
      S. Tominaga, T. Sugahara, S. Nishimoto, M. Yamawaki, Y. Nakashima, T. Kishida, K. Akiyama, M. Maruyama and S. Yamauchi
    • Total Pages
      345-351
    • Publisher
      Animal Cell Technology : Basic & Applied Aspects
  • [Remarks] ホームページ(愛媛大学農学部動物細胞工学教育分野)

    • URL

      http://web-amb.agr.ehime-u.ac.jp

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Published: 2013-07-31  

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