2011 Fiscal Year Final Research Report
Physiological functions of structured lipids
| Project/Area Number |
21580145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGAO Koji 佐賀大学, 農学部, 准教授 (10336109)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脂質構造異性体 / 高脂血症 / 動脈硬化 / 糖尿病 / 高血圧 |
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| Research Abstract |
The concept of a" structured-lipid" implies modification of the fatty acid composition and/ or their location in the glycerol backbone, and improvement of the physical and/ or physiological properties of dietary lipids. Our study demonstrated that bioactive lipids(such as conjugated linoleic acid and ozonized-olive oil) or structured lipids(such as dorphine-oil, n-3 structured lipids, and soy-PLs) displays at least two different physiological actions that alleviate obesity-induced diseases : one through the reduction of inflammatory damage by its suppression in productions of MCP-1 or PAI-1 and the other through an increase of adiponectin expression. Thus, possible findings on the effects of the form, such as PL, TAG or DAG, used for the administration of bioactive fatty acids, such as n-3 PUFA, CFA and MCFA, would be of great interest for future study.
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[Journal Article] Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow2010
Author(s)
R. Shiraishi, R. Iwakiri, T. Fujise, T. Kuroki, T. Kakimoto, T. Takashima, Y. Sakata, S. Tsunada, Y. Nakashima, T. Yanagita, K. Fujimoto
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Journal Title
J. Gastroenterol.
Volume: 45
Pages: 625-635
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[Journal Article] Effect of three different highly purified n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/ KsJ-db/ db Mice2009
Author(s)
N. Gotoh, K. Nagao, S. Onoda, B. Shirouchi, K. Furuya, T. Nagai, H. Mizobe, K. Ichioka, H. Watanabe, T. Yanagita, S. Wada
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Journal Title
J. Agric. Food Chem.
Volume: 57
Pages: 11047-11054
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