2011 Fiscal Year Final Research Report
Effect of lipid peroxidation on allergic reaction
| Project/Area Number |
21580146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kitami Institute of Technology |
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Principal Investigator |
ARAI Hirofumi 北見工業大学, 工学部, 准教授 (70295848)
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| Co-Investigator(Kenkyū-buntansha) |
TAKASUGI MIKAKO 九州産業大学, 工学部, 准教授 (60305802)
YAMADA Koji 九州大学, 農学部, 教授 (60158186)
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| Project Period (FY) |
2009 – 2011
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| Keywords | アレルギー / 活性酸素 / 脂質 / 酸化 |
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| Research Abstract |
Effect of lipid hydroperoxides which could be physiologically produced by reactive oxygen species on allergy reaction was investigated by using cultured cells in vitro. Mast cell line, a kind of white blood cell associated with allergy reaction was cultured and stimulated artificially. The chemical mediators such as histamine released from mast cells were facilitated by 4-hydroxy-2-nonenal, a decomposed product from lipid hydroperoxides. It suggests that lipid peroxidation might deteriorate allergy.
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