2011 Fiscal Year Final Research Report
Effect of lipid peroxidation on allergic reaction
Project/Area Number |
21580146
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Kitami Institute of Technology |
Principal Investigator |
ARAI Hirofumi 北見工業大学, 工学部, 准教授 (70295848)
|
Co-Investigator(Kenkyū-buntansha) |
TAKASUGI MIKAKO 九州産業大学, 工学部, 准教授 (60305802)
YAMADA Koji 九州大学, 農学部, 教授 (60158186)
|
Project Period (FY) |
2009 – 2011
|
Keywords | アレルギー / 活性酸素 / 脂質 / 酸化 |
Research Abstract |
Effect of lipid hydroperoxides which could be physiologically produced by reactive oxygen species on allergy reaction was investigated by using cultured cells in vitro. Mast cell line, a kind of white blood cell associated with allergy reaction was cultured and stimulated artificially. The chemical mediators such as histamine released from mast cells were facilitated by 4-hydroxy-2-nonenal, a decomposed product from lipid hydroperoxides. It suggests that lipid peroxidation might deteriorate allergy.
|